DCP1A, decapping mRNA 1A, 55802

N. diseases: 9; N. variants: 1
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.020 AlteredExpression disease BEFREE Higher DCP1A expression was significantly correlated with shorter DSS time in patients with MM (P<0.05). 29076924 2018
CUI: C0025202
Disease: melanoma
melanoma 		0.020 GeneticVariation disease BEFREE The rs11551405 A allele, located at the 3' UTR microRNA binding site of DCP1A, was associated with an increased risk of melanoma disease-specific death in both discovery dataset [adjusted Hazards ratio (HR) = 1.66, 95% confidence interval (CI) = 1.21-2.27, p =1.50 × 10<sup>-3</sup> ] and validation dataset (HR = 1.55, 95% CI = 1.03-2.34, p = 0.038), compared with the C allele, and their meta-analysis showed an HR of 1.62 (95% CI, 1.26-2.08, p =1.55 × 10<sup>-4</sup> ). 27578485 2016