PRKCZ, protein kinase C zeta, 5590

N. diseases: 88; N. variants: 8
Disease: Hyperinsulinism ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.020 Biomarker disease BEFREE Combined Hyperglycemia- and Hyperinsulinemia-Induced Insulin Resistance in Adipocytes Is Associated With Dual Signaling Defects Mediated by PKC-ζ. 29370351 2018
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.020 Biomarker disease BEFREE Furthermore, either kinase-dead PKCζ expression (KD-PKCζ) or disruption of PKCζ in mouse β-cells blocks compensatory β-cell replication when acute hyperglycemia/hyperinsulinemia is induced. 26868297 2016