Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.050 Biomarker group BEFREE Overall and cancer specific survival (OS, CSS) were estimated using Kaplan-Meier method and differences were compared using log-rank test. 31179077 2019
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.050 Biomarker group BEFREE Overall and cancer specific survival (OS, CSS) were estimated using Kaplan-Meier method and differences were compared using log-rank test. 31179077 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.050 Biomarker group BEFREE Two-year cancer-specific (2y-CSS) and 2-year overall survival (2y-OS) related to histopathological tumor stage of RARC patients calculated by Kaplan-Meier method were compared to ORC patients using log-rank test. 30045033 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.050 AlteredExpression group BEFREE The pooled results indicated that higher Gal-9 expression in cancer tissue associated with an improved CSS (HR=0.48, 95% CI 0.39-0.58). 29428936 2018
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.050 Biomarker group BEFREE Two-year cancer-specific (2y-CSS) and 2-year overall survival (2y-OS) related to histopathological tumor stage of RARC patients calculated by Kaplan-Meier method were compared to ORC patients using log-rank test. 30045033 2018
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.050 AlteredExpression group BEFREE The pooled results indicated that higher Gal-9 expression in cancer tissue associated with an improved CSS (HR=0.48, 95% CI 0.39-0.58). 29428936 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.050 GeneticVariation group BEFREE Eight cancer hallmark-based gene signatures (30 genes each) were identified and used to construct CSS sets for determining prognosis. 26502222 2016
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.050 GeneticVariation group BEFREE Eight cancer hallmark-based gene signatures (30 genes each) were identified and used to construct CSS sets for determining prognosis. 26502222 2016
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.050 Biomarker group BEFREE The expression of Dicer in colorectal carcinoma shows a strong association with poor survival (cancer specific survival=CSS, p<0,001) as well as with reduced progression free survival (PFS, p<0,001). 21345667 2011
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.050 Biomarker group BEFREE The expression of Dicer in colorectal carcinoma shows a strong association with poor survival (cancer specific survival=CSS, p<0,001) as well as with reduced progression free survival (PFS, p<0,001). 21345667 2011
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.040 AlteredExpression disease BEFREE Moreover, low CMAS gene expression correlated with reduced recurrence-free survival in a human colorectal cancer cohort, supporting the clinical relevance of our work. 30578646 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.040 Biomarker disease BEFREE The presence of LVI was the only independent and statistically significant prognostic variable for CSS in our cohort of pTNM stage I CRCs. 30018674 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.040 Biomarker group BEFREE Two-year cancer-specific (2y-CSS) and 2-year overall survival (2y-OS) related to histopathological tumor stage of RARC patients calculated by Kaplan-Meier method were compared to ORC patients using log-rank test. 30045033 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.040 Biomarker group BEFREE <b>Results:</b> In the SEER cohort, CSS differences increased as the tumor enlarged until a threshold tumor size group (tumor measuring 7-8 cm, <i>P</i> < 0.001) was reached, in which node positivity showed the maximum negative effect on CSS; multivariate Cox analyses showed that tumors measuring 7-8 cm presented a significant lower risk of cancer-specific mortality compared with those measuring 2-4 cm [hazard ratio (HR) = 1.087; 95% confidence interval (CI) = 1.014-1.165, <i>P</i> = 0.018]. 30619744 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.040 Biomarker group BEFREE In conclusion, primary tumor LN status was a strong predictor of CSS after palliative resection of metastatic colorectal cancer. 28430643 2017
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.040 Biomarker disease BEFREE The CSS sets were validated in 11 independent cohorts of 767 patients with stage II CRC who did not receive adjuvant chemotherapy. 26502222 2016
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.040 Biomarker group BEFREE BAP1 mutations tend to occur in Fuhrman grade III-IV tumors (p = 0.052) and are associated with worse CSS (p = 0.01). 23036577 2013
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.040 AlteredExpression disease BEFREE The expression of Dicer in colorectal carcinoma shows a strong association with poor survival (cancer specific survival=CSS, p<0,001) as well as with reduced progression free survival (PFS, p<0,001). 21345667 2011
Conventional (Clear Cell) Renal Cell Carcinoma
0.030 AlteredExpression disease BEFREE We found that in ccRCC, high interleukin (IL)-23 expression was significantly associated with poor survival in both TCGA (overall survival [OS] hazard ratio [HR]=2.04, cancer-specific survival [CSS] HR=2.95; all p<0.001) and Shanghai (OS HR=2.07, CSS HR=3.92; all p<0.001) cohorts. 30293904 2019
Conventional (Clear Cell) Renal Cell Carcinoma
0.030 AlteredExpression disease BEFREE Results showed that high Ki-67 expression in RCC was associated with poor OS (HR = 1.95, 95% CI: 1.44-2.64), CSS (HR = 1.67, 95% CI: 1.47-1.89), and DFS (HR = 2.56, 95% CI: 1.79-3.67). 28287186 2017
Conventional (Clear Cell) Renal Cell Carcinoma
0.030 GeneticVariation disease BEFREE Most mutations of chromatin modulators discovered in ccRCC are loss of function, associated with advanced stage, grade, and possibly worse CSS. 23036577 2013
CUI: C0042384
Disease: Vasculitis
Vasculitis
0.020 Biomarker disease BEFREE As described in the results, CSS were the most frequent cases reported, belonging to the Vasculitis category. 31837440 2020
CUI: C3714756
Disease: Intellectual Disability
Intellectual Disability
0.020 GeneticVariation group BEFREE Before the present study, no links between mutations in CMAS and incidences of human ID had been reported. 31495922 2020
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.020 Biomarker phenotype BEFREE Surgery was not associated with increased OS and CSS for UTEC with celiac or supraclavicular node metastasis but was favored as a predictor of better OS and CSS for LTEC with celiac or supraclavicular node metastasis. 31293066 2019
CUI: C0265338
Disease: Coffin-Siris syndrome
Coffin-Siris syndrome
0.020 Biomarker disease BEFREE Interestingly, the two resulting CPs, [Ag(Py-4-CSS)] <sub>n</sub> 1 and [Ag<sub>2</sub>(Py-4-CSS)(Py-4-CSSS)] <sub>n</sub> 2 (Py-4-CSS = pyridine-4-dithiocarboxylate; Py-4-CSSS = pyridine-4-perthiocarboxylate), show disparate structures due to the varied coordination mode of the pyridine group. 31038933 2019