Disease: Colon Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.030 Biomarker disease BEFREE Loss of MLH1 sensitizes colon cancer cells to DNA-PKcs inhibitor KU60648. 28224663 2017
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.030 Biomarker disease BEFREE Taken together, these results demonstrate a role for both AKT1 and AKT2 in radiotherapy response in colon cancer cells involving DNA repair capacity through the nonhomologous end joining pathway, thus suggesting that AKT in combination with DNA-PKcs inhibition may be used for radiotherapy sensitizing strategies in colon cancer. 24338765 2014
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.030 Biomarker disease BEFREE DNA-PKcs proficient and deficient syngeneic colon carcinoma sublines of HCT116 and the glioblastoma cell lines MO59K and MO59J as well as the lung carcinoma cell line A549 were used. 21723633 2011