APOM, apolipoprotein M, 55937

N. diseases: 82; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Insulin-Dependent
0.130 Biomarker disease BEFREE There were no differences in plasma levels of apoM and S1P between controls and T1D patients, but the apoM/S1P complexes were shifted from dense to light HDL particles in T1D. 28385702 2017
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.130 GeneticVariation disease BEFREE These findings suggest that the functional single-nucleotide polymorphism APOM rs805297 G/T variant allele was associated with RA risk. 23660425 2014
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.130 GeneticVariation disease BEFREE Recently, apoM polymorphisms have been related with RA susceptibility. 23190940 2013
Diabetes Mellitus, Insulin-Dependent
0.130 Biomarker disease BEFREE Apolipoprotein M can discriminate HNF1A-MODY from Type 1 diabetes. 23157689 2013
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.130 GeneticVariation disease GWASCAT Common variants at the promoter region of the APOM confer a risk of rheumatoid arthritis. 21844665 2011
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.130 GeneticVariation disease GWASDB Common variants at the promoter region of the APOM confer a risk of rheumatoid arthritis. 21844665 2011
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.130 GeneticVariation disease BEFREE Through GWAS, we identified a novel SNP associated with RA at the APOM gene in the MHC class III region on 6p21.33 (rs805297, odds ratio (OR) = 2.28, P = 5.20 × 10-7). 21844665 2011
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.130 GeneticVariation disease GWASDB A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis. 21156761 2011
Diabetes Mellitus, Insulin-Dependent
0.130 GeneticVariation disease BEFREE In the present study, we investigate the potential association between the ApoM promoter polymorphisms and type 1 diabetes. 19007767 2009
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.130 GeneticVariation disease GWASDB TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study. 17804836 2007
Diabetes Mellitus, Insulin-Dependent
0.130 GeneticVariation disease GWASDB A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. 17632545 2007
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic
0.120 Biomarker disease BEFREE Plasma concentrations of apoM were measured by ELISA in two patient groups with systemic lupus erythematosus (SLE) and in 79 healthy control individuals. 31046824 2019
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic
0.120 Biomarker disease BEFREE No association between APOM and SLE susceptibility was detected in our Han Chinese cohort. 28476116 2017
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic
0.120 GeneticVariation disease GWASDB GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region. 24871463 2014
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.110 Biomarker disease BEFREE Apolipoprotein M promotes proliferation and invasion in non-small cell lung cancers via upregulating S1PR1 and activating the ERK1/2 and PI3K/AKT signaling pathways. 29750961 2018
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.110 GeneticVariation disease GWASDB Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls. 22899653 2012
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.110 GeneticVariation disease GWASDB Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. 19654303 2009
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.110 GeneticVariation disease GWASDB Common 5p15.33 and 6p21.33 variants influence lung cancer risk. 18978787 2008
Diabetes Mellitus, Non-Insulin-Dependent
0.100 AlteredExpression disease BEFREE Obesity, metabolic syndrome and type 2 diabetes are associated with low circulating ApoM and adipose tissue APOM expression. 31815756 2020
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.100 AlteredExpression disease BEFREE The axis of apolipoprotein M (apoM) and sphingosine-1-phosphate (S1P) is of importance to plasma lipid levels, endothelial function, and development of atherosclerosis. 30433864 2019
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.100 Biomarker disease BEFREE In spite of the important role of Apolipoprotein-M (ApoM) and Sphingosine-1-Phosphate (S1P) played in atherosclerosis (AS), there was few related research reporting ApoM and S1P complex (ApoM-S1P) on biological activities of human umbilical vein endothelial cells (HUVECs). 31791242 2019
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.100 Biomarker disease BEFREE To clarify what role apoM plays in atherosclerosis, we used oxidized low-density lipoprotein (ox-LDL) to induce an inflammatory model of atherosclerosis. 30377890 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.100 AlteredExpression disease BEFREE The axis of apolipoprotein M (apoM) and sphingosine-1-phosphate (S1P) is of importance to plasma lipid levels, endothelial function, and development of atherosclerosis. 30433864 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.100 Biomarker disease BEFREE In spite of the important role of Apolipoprotein-M (ApoM) and Sphingosine-1-Phosphate (S1P) played in atherosclerosis (AS), there was few related research reporting ApoM and S1P complex (ApoM-S1P) on biological activities of human umbilical vein endothelial cells (HUVECs). 31791242 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.100 Biomarker disease BEFREE To clarify what role apoM plays in atherosclerosis, we used oxidized low-density lipoprotein (ox-LDL) to induce an inflammatory model of atherosclerosis. 30377890 2019