|
Glioblastoma Multiforme
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, prodigiosin caused cell death by activating the JNK pathway and decreasing the AKT/mTOR pathway in glioblastoma cells.
|
29721785 |
2018 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.370 |
Biomarker
|
disease |
BEFREE |
Interleukin-33 Predicts Poor Prognosis and Promotes Renal Cell Carcinoma Cell Growth Through its Receptor ST2 and the JNK Signaling Pathway.
|
29763892 |
2018 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.370 |
Biomarker
|
disease |
BEFREE |
The Adenosine A1 Receptor Antagonist DPCPX Inhibits Tumor Progression via the ERK/JNK Pathway in Renal Cell Carcinoma.
|
28950257 |
2017 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.370 |
Biomarker
|
disease |
BEFREE |
MicroRNA-10b Promotes Apoptosis via JNK Pathway in Clear Cell Renal Cell Carcinoma.
|
29672315 |
2018 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.370 |
Biomarker
|
disease |
BEFREE |
Periostin promotes migration and invasion of renal cell carcinoma through the integrin/focal adhesion kinase/c-Jun N-terminal kinase pathway.
|
28381189 |
2017 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.370 |
Biomarker
|
disease |
BEFREE |
RASSF6-mediated inhibition of Mcl-1 through JNK activation improves the anti-tumor effects of sorafenib in renal cell carcinoma.
|
29864454 |
2018 |
|
Malignant neoplasm of stomach
|
0.350 |
Biomarker
|
disease |
BEFREE |
Diallyl trisulfide suppresses tumor growth through the attenuation of Nrf2/Akt and activation of p38/JNK and potentiates cisplatin efficacy in gastric cancer treatment.
|
28344324 |
2017 |
|
Malignant neoplasm of stomach
|
0.350 |
Biomarker
|
disease |
CTD_human |
We investigated whether JNK1, a major JNK isozyme, is involved in chemically induced gastric cancer development.
|
18593901 |
2008 |
|
Malignant neoplasm of stomach
|
0.350 |
Biomarker
|
disease |
BEFREE |
Importantly, activated Pak1 elicited phosphorylation of the ERK and JNK-dependent pathway in gastric cancer cell lines.
|
22293972 |
2012 |
|
Malignant neoplasm of stomach
|
0.350 |
Biomarker
|
disease |
BEFREE |
In conclusions, RASSF10 functions as a tumor suppressor by cooperating with GSTP1 to deregulate JNK/c-Jun/AP-1 pathway in GC.
|
26279301 |
2016 |
|
Hyperalgesia
|
0.330 |
Biomarker
|
phenotype |
BEFREE |
Together, our data suggest that central ERK is involved in the analgesic and hyperalgesic effects of morphine while JNK, p38, and CREB are involved in the morphine-induced delayed hyperalgesia.
|
31616243 |
2019 |
|
Hyperalgesia
|
0.330 |
Biomarker
|
phenotype |
CTD_human |
Resveratrol suppresses glial activation and alleviates trigeminal neuralgia via activation of AMPK.
|
27093858 |
2016 |
|
Dermatitis, Atopic
|
0.320 |
Biomarker
|
disease |
BEFREE |
Activation of RhoA, Smad2, c-Src, PKC-βII/δ and JNK in atopic dermatitis.
|
29498756 |
2018 |
|
Dermatitis, Atopic
|
0.320 |
Biomarker
|
disease |
CTD_human |
JNK1-/- mice showed less ear thickening and infiltration of eosinophils and mast cells in AD-like lesions than did WT mice when treated with MC903.
|
24046278 |
2013 |
|
Liver Failure, Acute
|
0.320 |
Biomarker
|
disease |
BEFREE |
Sab<sup>ΔHep</sup> mice or Jnk1+2<sup>ΔHep</sup> mice did not develop ALF following administration of VPA and APAP.
|
31029706 |
2019 |
|
Liver Failure, Acute
|
0.320 |
Biomarker
|
disease |
BEFREE |
We found in human and murine samples of ibuprofen-induced acute liver failure that JNK phosphorylation was increased in the cytoplasm of hepatocytes and other non-liver parenchymal cells (non-LPCs) compared with healthy tissue.
|
30264435 |
2019 |
|
Liver Failure, Acute
|
0.320 |
Biomarker
|
disease |
CTD_human |
Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure.
|
17185352 |
2007 |
|
Mechanical Allodynia
|
0.320 |
Biomarker
|
phenotype |
BEFREE |
Ligustilide Relieves Complete Freund's Adjuvant-induced Mechanical Hyperalgesia through Inhibiting the Activation of Spinal c-Jun N-terminal Kinase/c-Jun Pathway in Rats.
|
29200725 |
2019 |
|
Mechanical Allodynia
|
0.320 |
Biomarker
|
phenotype |
BEFREE |
It was also showed that both the JNK inhibitor SP600125 and the NF-κB inhibitor PDTC significantly attenuated thermal hyperalgesia and mechanical allodynia in CCI rats.
|
27895138 |
2017 |
|
Mechanical Allodynia
|
0.320 |
Biomarker
|
phenotype |
CTD_human |
Resveratrol suppresses glial activation and alleviates trigeminal neuralgia via activation of AMPK.
|
27093858 |
2016 |
|
Mental Depression
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Genistein prevents nuclear factor-kappa B activation and acute lung injury induced by lipopolysaccharide.
|
11751189 |
2001 |
|
Mental Depression
|
0.310 |
Biomarker
|
disease |
PSYGENET |
NHE1 mediates MDA-MB-231 cells invasion through the regulation of MT1-MMP.
|
21669197 |
2011 |
|
Depressive disorder
|
0.310 |
Biomarker
|
disease |
PSYGENET |
NHE1 mediates MDA-MB-231 cells invasion through the regulation of MT1-MMP.
|
21669197 |
2011 |
|
Depressive disorder
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Genistein prevents nuclear factor-kappa B activation and acute lung injury induced by lipopolysaccharide.
|
11751189 |
2001 |
|
Schizophrenia
|
0.310 |
Biomarker
|
disease |
BEFREE |
ULK4 modulates multiple signalling pathways that include ERK, p38, PKC and JNK, which are involved in stress responses and implicated in schizophrenia.
|
24284070 |
2014 |