PRNP, prion protein, 5621

N. diseases: 426; N. variants: 47
Disease: impaired motor coordination ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0814161
Disease: impaired motor coordination
impaired motor coordination 		0.010 Biomarker phenotype BEFREE After long-term observation, we noted impaired motor coordination and loss of cerebellar Purkinje cells in the aged mice homozygous for a disrupted PrP gene, a finding which strongly suggests that PrPC plays a role in the long-term survival of Purkinje cells.3. 9876879 1998