|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These results imply that PPI might be modulated by four genotypes - COMT rs4680 (primarily in males), GRIK3 rs1027599, TCF4 rs9960767, and PRODH rs385440 - indicating a role of these gene variations in the development of early information processing deficits in schizophrenia.
|
29287625 |
2018 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis suggests that rs372055 (C/T) polymorphism in PRODH gene is associated with increased SZ risk only in Asian.
|
29047040 |
2018 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Mutations in the proline dehydrogenase gene <i>PRODH</i> are linked to behavioral alterations in schizophrenia and as part of DiGeorge and velo-cardio-facial syndromes, but the role of PRODH in their etiology remains unclear.
|
28331058 |
2017 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The proline dehydrogenase (PRODH) gene, which encodes the enzyme that catalyzes proline catabolism, maps to human chromosome 22q11.2, a region conferring risk of schizophrenia.
|
27622935 |
2016 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Therefore, our study investigates the effects of 12 polymorphisms of PRODH on schizophrenia and its phenotypes.
|
24498354 |
2014 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
PRODH maps to chromosome 22q11, a region conferring the highest known genetic risk of schizophrenia, and encodes proline oxidase, which catalyzes proline catabolism. l-Proline is a neuromodulator at glutamatergic synapses, and peripheral hyperprolinemia has been associated with decreased IQ, cognitive impairment, schizoaffective disorder, and schizophrenia.
|
24787057 |
2014 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We investigated two neurophysiological endophenotypes of schizophrenia - P50 sensory gating and mismatch negativity in 22q11.2DS subject and evaluated their association with catechol O-methyltransferase (COMT) and proline dehydrogenase (PRODH) genetic variants.
|
23910792 |
2013 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
PRODH is one of the candidate genes for susceptibility to schizophrenia and other neurological disorders.
|
24218577 |
2013 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We assessed the relationship between these high-risk PRODH polymorphisms and schizophrenia-related endophenotypes in a large and highly homogeneous cohort of healthy males.
|
19232576 |
2009 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Our findings suggest a role for functional genetic variation in POX on neostriatal-frontal circuits mediating risk and protection for schizophrenia.
|
18989458 |
2008 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
This study takes previous findings of association between PRODH and schizophrenia further by associating variation within the gene with performance on a neurocognitive trait characteristic of the illness.
|
18163391 |
2008 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
We sought to test whether a set of schizophrenia candidate genes regulated by hypoxia or involved in vascular function in the brain (AKT1, BDNF, CAPON, CHRNA7, COMT, DTNBP1, GAD1, GRM3, NOTCH4, NRG1, PRODH, RGS4, TNF-alpha) interacted with serious obstetric complications to influence risk for schizophrenia.
|
18195713 |
2008 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Overall, there is considerable evidence supporting a role for certain loss of function PRODH variants conferring risk for schizophrenia in some individuals.
|
18528746 |
2008 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest a role for functional genetic variation in POX on neostriatal-frontal circuits mediating risk and protection for schizophrenia.
|
18989458 |
2008 |
|
Schizophrenia
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Neither deletion extent nor PRODH haploinsufficiency appeared to explain the clinical expression of schizophrenia in the present study.
|
17028864 |
2007 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In a previous report [Jacquet et al., 2005] we have shown that mild to moderate hyperprolinemia resulting from several alterations (either a complete deletion or missense mutations) of the proline dehydrogenase (PRODH) gene located on chromosome 22q11 is a risk factor for schizoaffective disorder but not for DSM3 R schizophrenia or bipolar disorder.
|
16389584 |
2006 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Analysis of ProDH, COMT and ZDHHC8 risk variants does not support individual or interactive effects on schizophrenia susceptibility.
|
16860541 |
2006 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Systematic positional, expression and functional studies have implicated the regulator of G-protein signaling 4 (RGS4) and proline dehydrogenase (PRODH) genes as promising and novel candidates for explaining schizophrenia.
|
16791139 |
2006 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
These observations plus the high degree of polymorphism at the PRODH locus are consistent with the hypothesis that reduction in POX function is a risk factor for schizophrenia.
|
15662599 |
2005 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
CTD_human |
Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice.
|
16234811 |
2005 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Linkage disequilibrium mapping of the region in patients identified a segment containing two genes, proline dehydrogenase (PRODH) and DGCR6, as candidates [Liu et al., 2002a] and by analysis of additional polymorphisms the PRODH gene was associated with schizophrenia in adult and early onset patients.
|
15274030 |
2004 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Linkage disequilibrium mapping of the region in patients identified a segment containing two genes, proline dehydrogenase (PRODH) and DGCR6, as candidates [Liu et al., 2002a] and by analysis of additional polymorphisms the PRODH gene was associated with schizophrenia in adult and early onset patients.
|
15274030 |
2004 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
We conclude that any involvement of COMT and PRODH genes in schizophrenia is not accompanied by significant alterations in their overall mRNA expression, at least in dorsolateral prefrontal cortex.
|
14618678 |
2004 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Systematic examination of individual genes from the 1.5 Mb critical region has identified so far the PRODH and ZDHHC8 as strong candidate schizophrenia susceptibility genes from this locus.
|
15582150 |
2004 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|