PROX1, prospero homeobox 1, 5629

N. diseases: 114; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.460 GeneticVariation disease GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.460 GeneticVariation disease BEFREE The Type 2 Diabetes Susceptibility PROX1 Gene Variants Are Associated with Postprandial Plasma Metabolites Profile in Non-Diabetic Men. 31010169 2019
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.460 GeneticVariation disease GWASCAT Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes. 30054458 2018
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.460 GeneticVariation disease GWASCAT Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes. 29358691 2018
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.460 GeneticVariation disease BEFREE PROX1 gene CC genotype as a major determinant of early onset of type 2 diabetes in slavic study participants from Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation study. 28060188 2017
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.460 GeneticVariation disease BEFREE HHEX and PROX1 are genetic loci associated with diabetes mellitus type 2. 27684496 2017
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.460 GeneticVariation disease GWASCAT Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. 28869590 2017
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.460 AlteredExpression disease BEFREE All together, we propose that reduced expression of PROX1 by cis-regulatory variants results in altered β-cell insulin secretion and thereby confers susceptibility to type 2 diabetes. 23274905 2013
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.460 GeneticVariation disease BEFREE We identified a significant association of a SNP of FADS1 and a SNP near PROX1 with T2D in a Japanese population. 22992776 2012
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.460 GeneticVariation disease GWASDB Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. 22885922 2012
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.460 GeneticVariation disease BEFREE Further adjusting age, gender and BMI as confounders found PROX1 rs340874 was associated with type 2 diabetes (p = 0.0391). 21103350 2010
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.460 Biomarker disease CTD_human We also demonstrated association of ADCY5, PROX1, GCK, GCKR and DGKB-TMEM195 with type 2 diabetes. 20081858 2010
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.380 Biomarker phenotype BEFREE Our transcriptional analysis of <i>PROX1-</i>depleted follicular thyroid carcinoma cells followed by functional and phenotypical analyses provide, for the first time, evidence that PROX1 plays an important role in the metastasis of thyroid cancer cells by regulating genes involved in focal adhesion and cytoskeleton organization in tumour cells. 31060342 2019
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.380 AlteredExpression phenotype BEFREE In addition, PROX1 expression was correlated with perineural invasion, local regional recurrence, and distant metastasis of patients with SACC (P < .05), and no significant association was found between PROX1 expression and other clinicopathologic parameters. 29406257 2018
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.380 Biomarker phenotype BEFREE Together, our data provides a new insight into mechanism that DAB2IP regulates EMT and PCa metastasis, especially points out the potential roles of its downstream PROX1/HIF1α signaling in a unique non-skeletal metastasis of PCa. 27476001 2016
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.380 AlteredExpression phenotype BEFREE Patients with higher PROX1 expression (n = 26) had increased nuclear accumulation of HIF1α (p = 0.004) and more advanced metastasis, both lymph node (N factor; p = 0.09) and hematogenous (M factor; p = 0.04), than those with lower PROX1 expression (n = 91). 26310281 2015
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.380 AlteredExpression phenotype BEFREE Prox1 expression was significantly associated with local progression of the tumor (P = 0.0023), clinical stage (P<0.0001), lymphovessel density (LVD) (P<0.0001), nodal metastasis (P<0.0001), and worse prognosis (P<0.0001). 24647631 2014
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.380 AlteredExpression phenotype BEFREE These data identify PROX1 as a key regulator of the transcriptional network contributing to metastases outgrowth in colorectal cancer. 25242332 2014
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.380 AlteredExpression phenotype BEFREE A strong correlation between PROX1 mRNA amplification and regional lymph node metastasis supports its implications in cancer spreading and metastasis and sustains its utility, not only as a lymphatic marker, but also as a potential tumor marker in various tumor types, including gastric cancer. 24982352 2014
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.380 Biomarker phenotype BEFREE PROX1 is a critical factor that promotes HCC metastasis. 23505027 2013
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.380 Biomarker phenotype CTD_human Secondary, we analysed 38 brain metastases of primary breast carcinomas and detected a significantly reduced expression of PROX1 compared to normal breast tissue (p < 0.001) and primary breast carcinomas (p < 0.05), respectively. 17415710 2007
CUI: C0028754
Disease: Obesity
Obesity 		0.210 GeneticVariation disease BEFREE Combined linkage and association analyses identify a novel locus for obesity near PROX1 in Asians. 23818313 2013
CUI: C0028754
Disease: Obesity
Obesity 		0.210 Biomarker disease MGD Prox1 heterozygous mice are a new model for adult-onset obesity and lymphatic vascular disease. 16170315 2005
CUI: C0028754
Disease: Obesity
Obesity 		0.210 Biomarker disease MGD Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina. 12692551 2003
CUI: C0028754
Disease: Obesity
Obesity 		0.210 Biomarker disease MGD Prox1 function is crucial for mouse lens-fibre elongation. 10080188 1999