|
Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The brains of PRS mice, which are similar to the brains of patients with SZ and BP disorder, show an ∼2-fold increased binding of DNMT1 to psychiatric candidate promoters (glutamic acid decarboxylase 67, Reelin, and brain-derived neurotrophic factor), leading to their hypermethylation, reduced expression, as well as the behavioral endophenotypes reminiscent of those observed in the above psychiatric disorders.
|
30397000 |
2019 |
|
Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Genetic studies have identified rare RELN variants as risk factors for psychiatric disorders.
|
31848032 |
2019 |
|
Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
We found that RELN rs736707 was significantly related with psychiatric disorders (schizophrenia, autism spectrum disorders and attention-deficit hyperactivity disorder) in Asian group (C vs T, OR=1.26, 95% CI=1.13-1.41, P<0.01, FDR<0.01), and rs7341475 was only significantly associated with reduced risk of schizophrenia in Caucasian (A vs G, OR=0.88, 95% CI=0.82-0.95, P<0.01, FDR<0.01).
|
28506622 |
2017 |
|
Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These results suggest that deficiency of Reelin-Dab1 signal in the dorsal forebrain is involved in the pathogenesis of some symptoms of human psychiatric disorders.
|
26762856 |
2017 |
|
Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Reelin (RELN) is identified as a risk gene for major psychiatric disorders such as schizophrenia (SCZ) and bipolar disorder (BPD).
|
26637325 |
2016 |
|
Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
In the present study, we looked for a potential association between suicide and the reelin gene as reelin has been associated previously with several psychiatric disorders, including depression.
|
27537376 |
2016 |
|
Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These data indicate that reelin is necessary for the correct maturation and refinement of GABAergic synaptic circuits in the postnatal PFC and therefore provide a mechanism for altered E/I balance of prefrontal circuits associated with psychiatric disorders.
|
28127276 |
2016 |
|
Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
To further clarify the connection between reelin and psychiatric disorders, we studied the factors that influence the expression of reelin gene (RELN) and its different isoforms.
|
21603580 |
2011 |
|
Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Although RELN appears to be critical for normal cerebral and cerebellar development, its role, if any, in the pathogenesis of psychiatric disorders remains unclear.
|
16958033 |
2007 |
|
Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
These data suggest the possibility that epigenetic aberration from the normal DNA methylation status of RELN may confer susceptibility to psychiatric disorders.
|
17310238 |
2007 |
|
Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These results demonstrate for the first time that dysregulation of Reelin and Bcl-2 may be responsible for some of the brain structural and behavioral abnormalities observed in autism.
|
11814262 |
2001 |