RELN, reelin, 5649

N. diseases: 178; N. variants: 52
Disease: Memory impairment ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.040 PosttranslationalModification phenotype BEFREE DNMT inhibitors prevented the high expression of DNMT1 and hypermethylation of reelin gene and reversed the transgenerationally memory deficits. 30666786 2019
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.040 Biomarker phenotype BEFREE Reelin deficit is related to an abnormal migration of neurons in dentate gyrus, and its deficit causes dentate gyrus abnormalities, which in turn has been associated with memory deficits in patients with TLE. 31150999 2019
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.040 Biomarker phenotype BEFREE Our findings highlight the physiological importance of Reelin in protecting the brain against Aβ-induced synaptic dysfunction and memory impairment. 26152694 2015
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.040 AlteredExpression phenotype BEFREE In mice carrying the APP(Swe/Ind) mutation (J20 mice), Reelin overexpression delays amyloid plaque formation and rescues the recognition memory deficits. 24599114 2014