PSEN1, presenilin 1, 5663

N. diseases: 369; N. variants: 155
Disease: Tumor Progression ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.010 AlteredExpression phenotype BEFREE This is in line with a parallel study showing that covalent oligomerization of ILEI is essential for EMT and tumor progression <i>in vivo</i> The structures and the activity data give some first insight into the relationship between dimerization and ILEI function as well as indicate an intriguing link between ILEI, the PS1-protease, TGF-β, and the TGF-β receptor 1. 28751379 2017