The stage-1 study showed association of the DAOA and PSEN2 genes with schizophrenia in a small sample; the stage-2 study with an expanded sample confirmed the disease association for 2-SNP and 3-SNP haplotypes, and the cis-phase interactions between rs2391191 and some other SNPs in the DAOA gene.
The stage-1 study showed association of the DAOA and PSEN2 genes with schizophrenia in a small sample; the stage-2 study with an expanded sample confirmed the disease association for 2-SNP and 3-SNP haplotypes, and the cis-phase interactions between rs2391191 and some other SNPs in the DAOA gene.
The present results suggest that the PSEN2 gene may be a novel candidate involved in the development of certain psychotic symptoms of schizophrenia although the initial finding needs further replication in a large sample size.
The present results suggest that the PSEN2 gene may be a novel candidate involved in the development of certain psychotic symptoms of schizophrenia although the initial finding needs further replication in a large sample size.
In tissue from the second collection, levels of PS2V were markedly elevated in some BP and SZ cases, but there was no overall difference between diagnostic groups.