K<sub>2P</sub>13.1 (THIK-1) channels are expressed in the human heart, and atrial K<sub>2P</sub>13.1 levels are reduced in patients with atrial fibrillation (AF) or heart failure.
K<sub>2P</sub>13.1 (THIK-1) channels are expressed in the human heart, and atrial K<sub>2P</sub>13.1 levels are reduced in patients with atrial fibrillation (AF) or heart failure.
K<sub>2P</sub>13.1 (THIK-1) channels are expressed in the human heart, and atrial K<sub>2P</sub>13.1 levels are reduced in patients with atrial fibrillation (AF) or heart failure.
Here we tested the hypothesis that perioperative CeA administration of tetrapentylammonium (TPA), a non-selective THIK-1 channel blocker and thereby inhibitor of microglia, attenuates development of chronic neuropathic pain and comorbid anxiety-like behavior.
In this study we aimed to identify the currently unknown DRG subpopulations expressing THIK1, and to investigate the relationship between the channel and both inflammatory and spontaneous pain in normal rats.