|
Retinoblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
CEA family syndrome. Abnormal carcinoembryonic antigen (CEA) levels in asymptomatic retinoblastoma family members.
|
1260660 |
1976 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Further serial studies are needed to determine whether changes in CEA titer can be indicators of polyp and/or cancer occurrence.
|
6851804 |
1983 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
By sedimentation of poly(A)-containing tumor RNA through a sucrose gradient, and by in vitro translation of each fraction of the gradient, the sedimentation coefficient of CEA-specific mRNA was found to be about 22 S.
|
6200032 |
1983 |
|
Secondary malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
This protein behaves similarly to CEA isolated from liver metastases of a colon tumor in its property of being resistant to cleavage by cyanogen bromide.
|
6200032 |
1983 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Further serial studies are needed to determine whether changes in CEA titer can be indicators of polyp and/or cancer occurrence.
|
6851804 |
1983 |
|
Colonic Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
This protein behaves similarly to CEA isolated from liver metastases of a colon tumor in its property of being resistant to cleavage by cyanogen bromide.
|
6200032 |
1983 |
|
polyps
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Further serial studies are needed to determine whether changes in CEA titer can be indicators of polyp and/or cancer occurrence.
|
6851804 |
1983 |
|
Gardner Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
CEA and genetics. Gardner's syndrome.
|
6851804 |
1983 |
|
Colorectal Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Comparison of two CEA assays in primary and recurrent large bowel carcinoma with different DNA ploidy pattern.
|
3816909 |
1986 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Both assays showed a similar number of 'false-negative' CEA levels pre-operatively--varying from 69% in aneuploid (AN) Dukes' A to 8% in AN Dukes' D tumours, and from 75% in near diploid (ND) Dukes' A to 40% in ND Dukes' D tumours.
|
3816909 |
1986 |
|
Carcinoma
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Pre-operative CEA levels were measured in 100 patients with large bowel carcinomas with different DNA ploidy pattern and serial post-operative determinations performed in the 64 who had been operated for cure.
|
3816909 |
1986 |
|
Colorectal Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Plasma CEA in large bowel carcinoma: which patients should be followed by regular postoperative measurements? Preliminary follow-up results in 100 patients with different tumor DNA-ploidy patterns.
|
3568033 |
1987 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Thirty-eight patients with AN and 28 patients with ND tumors were operated on for cure and had normal plasma CEA levels postoperatively.
|
3568033 |
1987 |
|
Small cell carcinoma of lung
|
0.050 |
Biomarker
|
disease |
BEFREE |
CEA was detectable in 5/6 SCLC cell lines but absent in non-SCLC, and its level seemed to correlate with those of DDC, NSE, and CK.
|
2438285 |
1987 |
|
Colonic Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
CEA mRNA is most strongly expressed in primary colon tumors and, to a lesser extent, in normal colonic tissue.
|
3033671 |
1987 |
|
Norrie disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
It thus seems that a low CEA output of ND tumors explains many of the "false-negative" CEA measurements in disseminated cases.
|
3568033 |
1987 |
|
Adenoma of large intestine
|
0.010 |
Biomarker
|
disease |
BEFREE |
Aneuploidy and expression of gastric-associated mucus antigens M1 and CEA in colorectal adenomas.
|
3544799 |
1987 |
|
Ulcerative Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Many polyps and dysplastic lesions in ulcerative colitis have phenotypic changes (blood group antigen, cytokeratins, CEA, TAG-72.3 antigen expression) and genetic changes (c-K-ras mutation, enhanced c-myc expression and pp60c-src activity) which are characteristic of invasive cancers.
|
3052255 |
1988 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
No circulating CEA was found in patients bearing widespread metastatic disease of MA-CEA positive lesions.
|
3235849 |
1989 |
|
Carcinoma
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Similarly to the 180 kd CEA molecules synthesized by carcinomas, the expression of the melanoma associated CEA like components (MA-CEA) is upregulated by IFN-alpha.
|
3235849 |
1989 |
|
Acute Promyelocytic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A pregnancy-specific beta 1-glycoprotein, a CEA gene family member, expressed in a human promyelocytic leukemia cell line, HL-60: structures of protein, mRNA and gene.
|
2789512 |
1989 |
|
Promyelocytic leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A pregnancy-specific beta 1-glycoprotein, a CEA gene family member, expressed in a human promyelocytic leukemia cell line, HL-60: structures of protein, mRNA and gene.
|
2789512 |
1989 |
|
Colorectal Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CEA mRNA was detectable by northern blot hybridization in 97% of the CRCs examined.
|
1962152 |
1991 |
|
Carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CEA mRNA was detected together with NCA mRNA in nine cultured cell lines, with the exception of the lung carcinoma A549 cell line, and in 19 colon tissue specimens, including carcinomas, adjacent noninvaded tissues and adenomas.
|
2067130 |
1991 |
|
Carcinoma breast stage IV
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
All mucin markers which were investigated showed improved sensitivity for metastatic breast cancer compared with the established marker CEA.
|
2068512 |
1991 |