RETN, resistin, 56729

N. diseases: 302; N. variants: 13
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 AlteredExpression disease BEFREE Data seem to suggest that lower levels of adiponectin, and higher levels of resistin can be predictive of a future diabetes in obese people, even years before the disease onset. 31811995 2020
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 Biomarker disease BEFREE It has been suggested that resistin is a linkage between obesity, inflammation and type two diabetes. 31820685 2019
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 Biomarker disease BEFREE Both systemic and adipose tissue resistin are linked to dysglycemia in these individuals and may be a potential biomarker for diabetes in this population. 30778042 2019
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 Biomarker disease BEFREE Further, resistin concentration was higher in PHEO patients with diabetes than in non-diabetic ones (p<0.001). 31738032 2019
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 Biomarker disease BEFREE Resistin, a cysteine-rich peptide, is associated with atherosclerosis and diabetes. 29615544 2018
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 GeneticVariation disease BEFREE Association of genetic variants in RETN, NAMPT and ADIPOQ gene with glycemic, metabolic traits and diabetes risk in a Chinese population. 29101068 2018
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 Biomarker disease BEFREE Several of these activities, together with the effect of ellagic acid on insulin, glycogen, phosphatases, aldose reductase, sorbitol accumulation, advanced glycation end-product formation, and resistin secretion, may explain its effects on metabolic syndrome and diabetes. 29847844 2018
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 Biomarker disease BEFREE Adipose tissue is an important endocrine organ that secretes a number of adipokines, like Resistin (RETN); it's an adipocytes-secreted cytokine and has been proposed as a link between obesity and diabetes. 28393393 2018
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 Biomarker disease BEFREE The adipokine resistin has been proposed to link obesity, insulin resistance and diabetes. 30353146 2018
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 AlteredExpression disease BEFREE In experiments reported among different human genetic groups as well as the patients with various disease such as diabetes, no significant correlation is shown between FBG and resistin level. 29991083 2018
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 AlteredExpression disease BEFREE Resistin levels in patients with CP and systemic inflammatory disorders such as diabetes, obesity, or rheumatoid arthritis was not significantly higher than the levels in patients with only CP. 27567495 2017
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 AlteredExpression disease BEFREE Thirty-seven patients (35.6%) had high aortic stiffness and higher percentages of diabetes (p = 0.001), were of older age (p = 0.001) and had higher waist circumference (p < 0.001), systolic blood pressure (p = 0.027), pulse pressure (p = 0.013), high-sensitivity C-reactive protein (p < 0.001) and resistin levels (p < 0.001) but lower estimated glomerular filtration rate (p = 0.009) compared to subjects with low aortic stiffness. 28806778 2017
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 Biomarker disease BEFREE This finding suggested an essential role of resistin in linking IR and hypertension, which may offer a novel target in clinic on the study of the association between diabetes and hypertension. 26917360 2016
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 AlteredExpression disease BEFREE Oligonol attenuated serum resistin and IL-6 levels and reduced glomerular hypertrophy and mesangial matrix expansion caused by diabetes. 26960417 2016
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 Biomarker disease BEFREE Resistin may be an important link between obesity and diabetes. 25656506 2015
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 AlteredExpression disease BEFREE Plasma resistin level is a potential molecular link between obesity and diabetes. 24123702 2014
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 Biomarker disease BEFREE In this review knowledge on resistin, including its structure, physiological role related to obesity and diabetes, as well as, gene sequence and phenotypic effects of the identified polymorphisms in human and domestic mammals is discussed. 24152833 2013
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 Biomarker disease BEFREE Resistin, a cysteine-rich adipocytokine, proposed as a link between obesity and diabetes in mice, was shown as a proinflammatory molecule in humans. 24282299 2013
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 Biomarker disease BEFREE Resistin is an adipocyte-secreted cytokine recently discovered and has been proposed as a link between obesity and diabetes. 23020084 2012
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 GeneticVariation disease BEFREE Using comprehensive linkage disequilibrium mapping, we genotyped tag single nucleotide polymorphisms (SNPs) in RETN and tested associations with plasma resistin levels, risk of diabetes, and glycemic traits. 19074981 2009
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 Biomarker disease BEFREE Resistin antagonizes insulin action in mouse, making it a potential therapeutic target for treating metabolic diseases such as diabetes. 19126543 2009
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 Biomarker disease BEFREE Resistin causes insulin resistance and diabetes in mice whereas in humans it is linked to inflammation and atherosclerosis. 18710472 2009
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 Biomarker disease BEFREE Resistin, an adipocyte-secreted cytokine recently discovered in mice, has been proposed as a link between obesity and diabetes. 15326567 2004
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 GeneticVariation disease BEFREE Transgenic mice that overexpress the resistin gene (Retn) in adipose tissue are insulin-resistant, whereas Retn (-/-) mice show lower fasting blood glucose, suggesting that the altered Retn promoter function could cause diabetes. 15338456 2004
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 Biomarker disease BEFREE Resistin, founding member of the resistin-like molecule (RELM) hormone family, is secreted selectively from adipocytes and induces liver-specific antagonism of insulin action, thus providing a potential molecular link between obesity and diabetes. 15155948 2004