Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Resistin levels are higher in OA patients than in healthy controls; however, the precise role of resistin in the pathogenesis of OA needs to be studied further.
|
30809105 |
2019 |
Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In multivariate analysis, COMP (OR 1.24, 95% CI 1.06 to 1.46), resistin (OR 1.26, 95% CI 1.07 to 1.48), MCP-1 (OR 1.10, 95% CI 0.07 to 1.48) and NGF (OR<0.001, 95% CI <0.001 to 0.25) were found to be independently associated with PsA versus OA.
|
30910989 |
2019 |
Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Beyond mechanical loading, adipokines, including leptin, visfatin, adiponectin, resistin and others, are demonstrated to have metabolic implications in the pathogenesis and progression in obesity-induced osteoarthritis by modulating the pro/anti-inflammatory and anabolic/catabolic balance, apoptosis, matrix remodeling and subchondral bone ossification.
|
30539776 |
2019 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study is to describe the longitudinal associations of serum levels of resistin with knee synovitis measures and structural abnormalities in patients with knee OA.
|
31444016 |
2019 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, we show how resistin promotes MCP-1 expression in OA synovial fibroblasts and monocyte migration.
|
30845380 |
2019 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We investigated the relationship between visfatin, resistin and miRNA in oxidative stress regulation, in human OA synovial fibroblasts.
|
31635187 |
2019 |
Degenerative polyarthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Resistin - 420 mutant genotype was associated with an increased susceptibility to OA (p = 0.001).
|
30903575 |
2019 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Visfatin and resistin regulate the expression levels of some miRNA involved in OA pathogenesis and exert catabolic functions in chondrocytes via the <i>NF-κB</i> pathway.
|
30563239 |
2018 |
Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These observations provide further indications that meniscal tissue is more sensitive to pro-inflammatory factors than cartilage and also suggest further study of resistin's role in OA.
|
28095064 |
2018 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To evaluate serum levels of visfatin, resistin and adiponectin in patients with erosive (E) and non-erosive (NE) osteoarthritis (OA) of the hand (HOA) compared to normal controls (NC).
|
29105498 |
2018 |
Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Adipokines (e.g., visfatin, resistin, leptin) are adipocyte-derived factors with immunomodulatory properties and might influence differentiation of bone marrow-derived mesenchymal stem cells (MSC) in osteoarthritis (OA) and osteoporosis (OP).
|
29908226 |
2018 |
Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of this study was, therefore, to assess the anti-inflammatory and analgesic effects of a garlic supplement on serum resistin and TNF-α concentrations and on pain severity in overweight or obese women with knee OA.
|
30195882 |
2018 |
Degenerative polyarthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Also, LEPR AC (OR 1.54, 95% CI 1.01-2.35, p = 0.05) and RETN GGTT (OR 0.58, 95% CI 0.37-0.93, p = 0.02) haplotypes were associated with hand OA.
|
28812414 |
2018 |
Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The roles of adiponectin and resistin in knee injury and osteoarthritis deserve further study.
|
27435997 |
2018 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of resistin and CAP1 in synovial tissue was stronger in RA than in osteoarthritis (OA).
|
29191223 |
2017 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Adiponectin, resistin, and visfatin were expressed in OA osteophytes by various articular cell types.
|
27884778 |
2017 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We found that human OA chondrocytes exposed to different modes of low shear stress elicit an opposite effect on resistin-induced COX-2 expression: pre-shear for a short duration attenuates the resistin effect by inhibiting the transcription factor nuclear factor (NF)-κB-p65 subunit and the cAMP response element binding protein; however, post-shear over a longer duration enhances the resistin effect by activating only the NF-κB-p65 subunit.
|
27731497 |
2017 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Serum levels of resistin were positively and independently associated with cartilage defects and BMLs in patients with knee OA.
|
27400438 |
2017 |
Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Stimulation of primary OA osteoblasts with recombinant resistin increased Wnt signalling activation, osteoblast metabolic activity, and bone nodule formation.
|
28642544 |
2017 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results support the hypothesis that high expression of resistin represents a significant and reproducible marker of poor progression in OA patients, especially in males.
|
25530956 |
2014 |