|
Liver carcinoma
|
0.320 |
Biomarker
|
disease |
CTD_human |
Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling.
|
28284560 |
2017 |
|
Liver carcinoma
|
0.320 |
Biomarker
|
disease |
BEFREE |
In current study, we identified the expression of 1810011o10 Rik, which is the homolog of human thyroid cancer 1, in intratumoral activated CD8<sup>+</sup> T cells in a murine hepatocellular carcinoma (HCC) implantation model.
|
28382040 |
2017 |
|
Liver carcinoma
|
0.320 |
Biomarker
|
disease |
BEFREE |
C8orf4 is located in the cytoplasm of HCC tumour cells and associates with the NOTCH2 intracellular domain, which impedes the nuclear translocation of N2ICD.
|
25985737 |
2015 |
|
Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
The thyroid cancer-1 (TC-1) or c8orf4 gene encodes a 106-residue naturally disordered protein that has been found to be associated with thyroid, gastric, and breast cancer.
|
23880650 |
2013 |
|
Malignant neoplasm of breast
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Previous studies have demonstrated that over expression of TC-1(C8orf4) mRNA occurs in approximately 50% of breast cancer cell lines and primary tumor specimens.
|
17520678 |
2007 |
|
Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
Thus, LSM1, BAG4, and C8orf4 are breast cancer oncogenes that can work in combination to influence the transformed phenotype in human mammary epithelial cells.
|
17178857 |
2006 |
|
Malignant neoplasm of thyroid
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Thyroid cancer 1 (TC1, C8orf4) plays important roles in many signaling pathways, such as Wnt/β-catenin signaling pathway, and is involved in the development of many cancers.
|
25869879 |
2015 |
|
Malignant neoplasm of thyroid
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The thyroid cancer-1 (TC-1) or c8orf4 gene encodes a 106-residue naturally disordered protein that has been found to be associated with thyroid, gastric, and breast cancer.
|
23880650 |
2013 |
|
Malignant neoplasm of thyroid
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer.
|
11056052 |
2000 |
|
Thyroid Neoplasm
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer.
|
11056052 |
2000 |
|
Thyroid Neoplasm
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The thyroid cancer-1 (TC-1) or c8orf4 gene encodes a 106-residue naturally disordered protein that has been found to be associated with thyroid, gastric, and breast cancer.
|
23880650 |
2013 |
|
Thyroid Neoplasm
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Thyroid cancer 1 (TC1, C8orf4) plays important roles in many signaling pathways, such as Wnt/β-catenin signaling pathway, and is involved in the development of many cancers.
|
25869879 |
2015 |
|
Thyroid carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer.
|
11056052 |
2000 |
|
Thyroid carcinoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The thyroid cancer-1 (TC-1) or c8orf4 gene encodes a 106-residue naturally disordered protein that has been found to be associated with thyroid, gastric, and breast cancer.
|
23880650 |
2013 |
|
Thyroid carcinoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Thyroid cancer 1 (TC1, C8orf4) plays important roles in many signaling pathways, such as Wnt/β-catenin signaling pathway, and is involved in the development of many cancers.
|
25869879 |
2015 |
|
Breast Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Previous studies have demonstrated that over expression of TC-1(C8orf4) mRNA occurs in approximately 50% of breast cancer cell lines and primary tumor specimens.
|
17520678 |
2007 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The thyroid cancer-1 (TC-1) or c8orf4 gene encodes a 106-residue naturally disordered protein that has been found to be associated with thyroid, gastric, and breast cancer.
|
23880650 |
2013 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Thus, LSM1, BAG4, and C8orf4 are breast cancer oncogenes that can work in combination to influence the transformed phenotype in human mammary epithelial cells.
|
17178857 |
2006 |
|
Myeloid Leukemia, Chronic
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We found significant association between the copy-number deletions of C8orf4 and the risk of these hematological malignancies including acute lymphoblastic leukemia (ALL), acute myelogenous leukemia (AML), chronic lymphocytic leukemia (CLL), chronic myelogenous leukemia (CML), multiple myeloma (MM), and myelodysplastic syndrome (MDS).
|
20878554 |
2011 |
|
Myeloid Leukemia, Chronic
|
0.020 |
Biomarker
|
disease |
BEFREE |
Granulocytes from patients with chronic myelogenous leukemia (CML) contain both TC I and TC III, and these R proteins can be released in vitro by lithium stimulation.
|
6949616 |
1982 |
|
Malignant neoplasm of urinary bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, the nearby genes pattern displayed that overexpressing ADAM2 and C8orf4 are cis-regulated by lncRNA RP11-359E19.2, involving in progression of bladder cancer.
|
27363013 |
2016 |
|
Bladder Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, the nearby genes pattern displayed that overexpressing ADAM2 and C8orf4 are cis-regulated by lncRNA RP11-359E19.2, involving in progression of bladder cancer.
|
27363013 |
2016 |
|
Malignant tumor of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
C8orf4 is a gene regulated by TGF beta signaling and loss in advanced colon cancer suggests C8orf4 may play a role in colon cell differentiation or growth regulation.
|
15185345 |
2004 |
|
Squamous cell carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The high expression of TC1 (C8orf4) was correlated with the expression of β-catenin and cyclin D1 and the progression of squamous cell carcinomas of the tongue.
|
25869879 |
2015 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Purpose</b>: The recent success of anti-PD1 antibody in metastatic colorectal cancer (CRC) patients with microsatellite instability (MSI), known to be associated with an upregulated Th1/Tc1 gene signature, provides new promising therapeutic strategies.
|
30906656 |
2019 |