|
Liver carcinoma
|
0.320 |
Biomarker
|
disease |
CTD_human |
Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling.
|
28284560 |
2017 |
|
Liver carcinoma
|
0.320 |
Biomarker
|
disease |
BEFREE |
In current study, we identified the expression of 1810011o10 Rik, which is the homolog of human thyroid cancer 1, in intratumoral activated CD8<sup>+</sup> T cells in a murine hepatocellular carcinoma (HCC) implantation model.
|
28382040 |
2017 |
|
Liver carcinoma
|
0.320 |
Biomarker
|
disease |
BEFREE |
C8orf4 is located in the cytoplasm of HCC tumour cells and associates with the NOTCH2 intracellular domain, which impedes the nuclear translocation of N2ICD.
|
25985737 |
2015 |
|
Malignant neoplasm of thyroid
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Thyroid cancer 1 (TC1, C8orf4) plays important roles in many signaling pathways, such as Wnt/β-catenin signaling pathway, and is involved in the development of many cancers.
|
25869879 |
2015 |
|
Thyroid Neoplasm
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Thyroid cancer 1 (TC1, C8orf4) plays important roles in many signaling pathways, such as Wnt/β-catenin signaling pathway, and is involved in the development of many cancers.
|
25869879 |
2015 |
|
Thyroid carcinoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Thyroid cancer 1 (TC1, C8orf4) plays important roles in many signaling pathways, such as Wnt/β-catenin signaling pathway, and is involved in the development of many cancers.
|
25869879 |
2015 |
|
Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
The thyroid cancer-1 (TC-1) or c8orf4 gene encodes a 106-residue naturally disordered protein that has been found to be associated with thyroid, gastric, and breast cancer.
|
23880650 |
2013 |
|
Malignant neoplasm of thyroid
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The thyroid cancer-1 (TC-1) or c8orf4 gene encodes a 106-residue naturally disordered protein that has been found to be associated with thyroid, gastric, and breast cancer.
|
23880650 |
2013 |
|
Thyroid Neoplasm
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The thyroid cancer-1 (TC-1) or c8orf4 gene encodes a 106-residue naturally disordered protein that has been found to be associated with thyroid, gastric, and breast cancer.
|
23880650 |
2013 |
|
Thyroid carcinoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The thyroid cancer-1 (TC-1) or c8orf4 gene encodes a 106-residue naturally disordered protein that has been found to be associated with thyroid, gastric, and breast cancer.
|
23880650 |
2013 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The thyroid cancer-1 (TC-1) or c8orf4 gene encodes a 106-residue naturally disordered protein that has been found to be associated with thyroid, gastric, and breast cancer.
|
23880650 |
2013 |
|
Malignant neoplasm of breast
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Previous studies have demonstrated that over expression of TC-1(C8orf4) mRNA occurs in approximately 50% of breast cancer cell lines and primary tumor specimens.
|
17520678 |
2007 |
|
Breast Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Previous studies have demonstrated that over expression of TC-1(C8orf4) mRNA occurs in approximately 50% of breast cancer cell lines and primary tumor specimens.
|
17520678 |
2007 |
|
Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
Thus, LSM1, BAG4, and C8orf4 are breast cancer oncogenes that can work in combination to influence the transformed phenotype in human mammary epithelial cells.
|
17178857 |
2006 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Thus, LSM1, BAG4, and C8orf4 are breast cancer oncogenes that can work in combination to influence the transformed phenotype in human mammary epithelial cells.
|
17178857 |
2006 |
|
Malignant neoplasm of thyroid
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer.
|
11056052 |
2000 |
|
Thyroid Neoplasm
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer.
|
11056052 |
2000 |
|
Thyroid carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer.
|
11056052 |
2000 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Integrin α2β1 mediated CAF EV uptake by lung fibroblasts, and its blockage by TC I-15 prevented lung pre-metastatic niche formation and subsequent metastasis.
|
31796058 |
2019 |
|
Myeloid Leukemia, Chronic
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We found significant association between the copy-number deletions of C8orf4 and the risk of these hematological malignancies including acute lymphoblastic leukemia (ALL), acute myelogenous leukemia (AML), chronic lymphocytic leukemia (CLL), chronic myelogenous leukemia (CML), multiple myeloma (MM), and myelodysplastic syndrome (MDS).
|
20878554 |
2011 |
|
Neoplasm Metastasis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Moreover, C8orf4 is expressed in most normal colon mucosa samples, and is not expressed in most colon cancer metastases or colon cancer cell lines.
|
15185345 |
2004 |
|
Myeloid Leukemia, Chronic
|
0.020 |
Biomarker
|
disease |
BEFREE |
Granulocytes from patients with chronic myelogenous leukemia (CML) contain both TC I and TC III, and these R proteins can be released in vitro by lithium stimulation.
|
6949616 |
1982 |
|
Malignant Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The Cancer Genome Atlas genomics data also confirmed that the mRNA expression of C8orf4 was positively associated with the copy number alteration of C8orf4 (correlation coefficient = 0.213, P < .001), and negatively correlated with the methylation level of C8orf4 (correlation coefficient = -0.408, P < .001).
|
31374065 |
2019 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Purpose</b>: The recent success of anti-PD1 antibody in metastatic colorectal cancer (CRC) patients with microsatellite instability (MSI), known to be associated with an upregulated Th1/Tc1 gene signature, provides new promising therapeutic strategies.
|
30906656 |
2019 |
|
Secondary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
TC I-15 was used to inhibit EV uptake by LFs and SACC lung metastasis in vivo.
|
31796058 |
2019 |