PDXP, pyridoxal phosphatase, 57026

N. diseases: 149; N. variants: 2
Disease: Multiple Sclerosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.040 GeneticVariation disease BEFREE Interestingly, we found mutant PLP-directed antibody response against specific mutant peptides in the sera of pre-MS controls. 28191734 2017
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.040 Biomarker disease BEFREE MBP-PLP fusion protein (MP4)-induced experimental autoimmune encephalomyelitis (EAE) is a model for multiple sclerosis (MS) that encompasses both a time-dependent attack on central nervous system (CNS) regions and a B cell component, mirroring important features of human multiple sclerosis. 20078558 2009
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.040 GeneticVariation disease BEFREE Results indicate that MAG, MBP, OMGP, and PLP genes do not have a significant genetic effect on susceptibility to MS in this population. 10541588 1999
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.040 GeneticVariation disease BEFREE Here we test the hypothesis that mutations in the human MBP and PLP genes might be associated with MS by examining the entire expressed sequence of both genes by single strand conformation polymorphism (SSCP) analysis, using a panel of 71 MS patients and 71 controls. 9460711 1997