The present study was designed to investigate the long‑term effect of prehypertensive losartan therapy on metabolic disorders in high‑fat‑fed spontaneously hypertensive rats (SHRs), and to examine the role of epigenetic regulation of angiotensin II type 1 receptor (AT1R) and AT1 receptor‑associated protein (ATRAP) expression in adipose tissue.
These results demonstrate that Agtrap(-/-) mice are an effective model of metabolic disorders with visceral obesity and constitute evidence that ATRAP plays a protective role against insulin resistance, suggesting a new therapeutic target in metabolic disorders.