Polycythemia Vera
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Within this context, elevated CD177 expression is not only a specific feature of PV but may be an indicator of increased erythropoietic activity in thalassaemia syndromes.
|
18324972 |
2008 |
Polycythemia Vera
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In polycythemia vera (PV) and essential thrombocythemia (ET) specific JAK2 mutations constitutively activate the JAK-STAT pathway, explaining biologic findings such as endogenous erythroid colony (EECs) growth or PRV-1 RNA overexpression.
|
18623127 |
2008 |
Polycythemia Vera
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, overexpression of the PRV-1 gene in PV and ET is associated with a decrease in methylation of this gene.
|
17976520 |
2007 |
Polycythemia Vera
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Biomarker analysis in polycythemia vera under interferon-alpha treatment: clonality, EEC, PRV-1, and JAK2 V617F.
|
17256145 |
2007 |
Polycythemia Vera
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These preliminary observations indicate that the Jak2(V617F) mutation in particular and PRV-1 overexpression appear to be suitable markers for monitoring treatment efficiency in prospective randomised clinical studies comparing pegylated interferon and hydroxyurea in well defined PV patients with a clear indication for cytoreductive therapy.
|
17852451 |
2007 |
Polycythemia Vera
|
0.100 |
Biomarker
|
disease |
BEFREE |
Levels of the mutation were significantly higher in polycythemia vera compared with essential thrombocythemia (P=0.0005) and correlated with the following jointly significant variables at diagnosis: PRV-1, hemoglobin, white cell count, neutrophil count, and red cell count, using multiple regression analyses (P=0.015).
|
17384217 |
2007 |
Polycythemia Vera
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PRV-1 mRNA is overexpressed by neutrophils from polycythemia vera patients and is homologous to NB1 a gene overexpressed in reactive neutrophilia.
|
16533288 |
2006 |
Polycythemia Vera
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, compared with the PRV-1 assay, mutation screening for JAK2(V617F) displayed greater accuracy in distinguishing PV from SP.
|
16197445 |
2005 |
Polycythemia Vera
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, quantifying neutrophil PRV-1 mRNA, while complementary to other tests, is not in itself sufficient for the diagnosis of PV.
|
14701686 |
2004 |
Polycythemia Vera
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we show that 40% of the PRV-1-positive patients develop symptoms of PV during the course of their disease.
|
15034760 |
2004 |
Polycythemia Vera
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The effects of hydroxyurea on PRV-1 expression in patients with essential thrombocythemia and polycythemia vera.
|
15477215 |
2004 |
Polycythemia Vera
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Instability of PRV-1 mRNA: a factor to be considered in PRV-1 quantification for the diagnosis of polycythemia vera.
|
15194544 |
2004 |
Polycythemia Vera
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Neutrophil PRV-1 expression across the chronic myeloproliferative disorders and in secondary or spurious polycythemia.
|
14701686 |
2004 |
Polycythemia Vera
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We studied neutrophil CD177 mRNA levels in normal subjects and in 235 patients with Ph-negative chronic myeloproliferative disorders (CMD), including PV, essential thrombocythaemia and myelofibrosis with myeloid metaplasia.
|
15327515 |
2004 |
Polycythemia Vera
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, overexpression of PRV-1 in granulocytes from patients with PV is related to mechanisms that do not involve structural genetic changes.
|
12591276 |
2003 |
Polycythemia Vera
|
0.100 |
Biomarker
|
disease |
BEFREE |
We concluded that, rather than an upregulation of the PRV-1 gene in the clonal haematopoiesis of polycythaemia vera, a failure to downregulate PRV-1 in granulocytes emigrating from the bone marrow might be responsible for the increase of transcripts in peripheral cells.
|
14617008 |
2003 |
Polycythemia Vera
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Because there is no overlap between the PRV-1 expression in PV patients versus healthy controls or SE patients, the assay has a very high sensitivity and specificity for the diagnosis of PV in our population.
|
12893745 |
2003 |
Polycythemia Vera
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
EECs were observed in 14 of 14 patients with PV and 4 of 12 with ET, and increased granulocyte PRV-1 mRNA levels were found in 9 of 13 patients with PV and 2 of 12 with ET.
|
12515724 |
2003 |
Polycythemia Vera
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Fluorescence in situ hybridization analysis of the PRV-1 gene in polycythemia vera: implications for its role in diagnosis and pathogenesis.
|
12591276 |
2003 |
Polycythemia Vera
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In 58 ET patients, a possible association between polycythaemia rubra vera-1 (PRV-1) overexpression and subnormal plasma EPO was investigated, which was always measured prior to the institution of platelet lowering agents.
|
12756017 |
2003 |
Polycythemia Vera
|
0.100 |
Biomarker
|
disease |
BEFREE |
We observed concordance between EECs and PRV-1 in MPD patients across all diagnostic subclasses, but our results indicate that EECs remain the most reliable auxiliary test for polycythemia vera (PV).
|
12730106 |
2003 |
Polycythemia Vera
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PRV-1 mRNA overexpression, is known to be present in the vast majority of patients with polycythaemia vera and also in some patients with ET.
|
14617016 |
2003 |
Polycythemia Vera
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The overexpression of PRV-1 seems to be a useful tool for discriminating ET and PV from ST and SE, thus offering an innovative diagnostic approach on the basis of the detection of positive diagnostic criteria instead of exclusion criteria.
|
12377969 |
2002 |
Polycythemia Vera
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have determined the intron-exon structure of the PRV1 gene and show that the locus is structurally intact in patients with polycythemia vera.
|
12239154 |
2002 |
Polycythemia Vera
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
On the contrary, all ET patients, 35 of 37 PV patients, and five patients with acute postsurgery and posttraumatic SL overexpressed PRV-1.
|
12377969 |
2002 |