|
Malignant tumor of colon
|
0.220 |
GeneticVariation
|
disease |
BEFREE |
Using principal component analysis to derive a numeric score representing pathway expression, we evaluated clinico-genomic datasets (n=427) from corresponding normal, pre-invasive and invasive cancers of different types, such as ovarian, endometrial, breast and colon cancers in order to determine the associations between the BAD-mediated apoptotic pathway and cancer development.
|
25653146 |
2015 |
|
Malignant tumor of colon
|
0.220 |
Therapeutic
|
disease |
RGD |
High energy shock waves and 5-aminolevulinic for sonodynamic therapy: effects in a syngeneic model of colon cancer.
|
21214291 |
2011 |
|
Malignant tumor of colon
|
0.220 |
GeneticVariation
|
disease |
BEFREE |
This is the first report on Bad gene mutation in human malignancies, and our data suggest that Bad gene is occasionally mutated in colon cancers and that somatic mutation of Bad may contribute to the development of colon cancers.
|
15033904 |
2004 |
|
Obesity
|
0.210 |
GeneticVariation
|
disease |
BEFREE |
Common BAD and SERPINA6 variants were associated (p<0.05) with obesity and insulin resistance, respectively.
|
29126409 |
2017 |
|
Obesity
|
0.210 |
Biomarker
|
disease |
RGD |
More activated cardiac mitochondrial-dependent apoptotic pathway in obese Zucker rats.
|
18070754 |
2007 |
|
Chemical and Drug Induced Liver Injury
|
0.200 |
Therapeutic
|
disease |
RGD |
Anti-apoptotic effect of San Huang Shel Shin Tang cyclodextrin complex (SHSSTc) on CCl4 -induced hepatotoxicity in rats.
|
25447754 |
2016 |
|
Sepsis
|
0.200 |
Biomarker
|
disease |
RGD |
Early inactivation of PKCε associates with late mitochondrial translocation of Bad and apoptosis in ventricle of septic rat.
|
24011917 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
RGD |
The hyperglycemia stimulated myocardial endoplasmic reticulum (ER) stress contributes to diabetic cardiomyopathy in the transgenic non-obese type 2 diabetic rats: a differential role of unfolded protein response (UPR) signaling proteins.
|
23032698 |
2013 |
|
Diabetic Neuropathies
|
0.200 |
Therapeutic
|
group |
RGD |
Traditional chinese medicine tang-luo-ning ameliorates sciatic nerve injuries in streptozotocin-induced diabetic rats.
|
24288572 |
2013 |
|
Intermittent Claudication
|
0.200 |
Biomarker
|
phenotype |
RGD |
Over-expression of PUMA correlates with the apoptosis of spinal cord cells in rat neuropathic intermittent claudication model.
|
23658678 |
2013 |
|
Mammary Neoplasms, Experimental
|
0.200 |
Therapeutic
|
phenotype |
RGD |
Chemopreventive effect of a novel oleanane triterpenoid in a chemically induced rodent model of breast cancer.
|
23404339 |
2013 |
|
Myocardial Reperfusion Injury
|
0.200 |
Therapeutic
|
phenotype |
RGD |
Activation of autophagy in ischemic postconditioning contributes to cardioprotective effects against ischemia/reperfusion injury in rat hearts.
|
23364609 |
2013 |
|
Gastric ulcer
|
0.200 |
Therapeutic
|
disease |
RGD |
Cytoprotective effect of American ginseng in a rat ethanol gastric ulcer model.
|
24378970 |
2013 |
|
Sepsis
|
0.200 |
Therapeutic
|
disease |
RGD |
Therapeutic hypothermia attenuates liver injury in polymicrobial sepsis model of rats via Akt survival pathway.
|
22683079 |
2013 |
|
Diabetic cystopathy
|
0.200 |
Therapeutic
|
disease |
RGD |
Protective effect of cyanidin-3-O-β-D-glucopyranoside fraction from mulberry fruit pigment against oxidative damage in streptozotocin-induced diabetic rat bladder.
|
23129268 |
2013 |
|
Brain Ischemia
|
0.200 |
Biomarker
|
disease |
RGD |
Cluster analysis of mRNA expression levels identifies multiple sequential patterns following focal cerebral ischemia.
|
22843461 |
2012 |
|
Pancreatitis, Chronic
|
0.200 |
ModifyingMutation
|
disease |
RGD |
p38MAPK suppresses chronic pancreatitis by regulating HSP27 and BAD expression.
|
22549003 |
2012 |
|
Parkinsonian Disorders
|
0.200 |
Biomarker
|
group |
RGD |
Endogenous repair by the activation of cell survival signalling cascades during the early stages of rat Parkinsonism.
|
23251488 |
2012 |
|
Infarction, Middle Cerebral Artery
|
0.200 |
Therapeutic
|
disease |
RGD |
Nicotinamide prevents the down-regulation of MEK/ERK/p90RSK signaling cascade in brain ischemic injury.
|
21891976 |
2012 |
|
Infarction, Middle Cerebral Artery
|
0.200 |
Therapeutic
|
disease |
RGD |
Ferulic acid prevents the cerebral ischemic injury-induced decrease of Akt and Bad phosphorylation.
|
22200499 |
2012 |
|
Diabetes Mellitus, Experimental
|
0.200 |
Biomarker
|
disease |
RGD |
Impaired epithelial wound healing and EGFR signaling pathways in the corneas of diabetic rats.
|
21330660 |
2011 |
|
Cardiomegaly
|
0.200 |
Therapeutic
|
phenotype |
RGD |
Exercise training improves systolic function in hypertensive myocardium.
|
21921241 |
2011 |
|
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
RGD |
Propylthiouracil-induced hypothyroidism delays apoptosis during the first wave of spermatogenesis.
|
22513421 |
2011 |
|
Insulin Resistance
|
0.200 |
Biomarker
|
phenotype |
RGD |
In parallel, myocardial peptide levels of apoptotic markers (caspase-3, cytochrome-c, BAD) were significantly higher with insulin resistance.
|
21385329 |
2011 |
|
Mammary Neoplasms, Experimental
|
0.200 |
ModifyingMutation
|
phenotype |
RGD |
Long-term hormonal promotion overcomes genetic resistance to mammary cancer.
|
20732338 |
2011 |