PTAFR, platelet activating factor receptor, 5724

N. diseases: 96; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.200 Therapeutic disease RGD Mechanisms of glomerular injury in experimental immune nephritis. II. Effect of a platelet activating factor receptor antagonist in an autologous nephritis model. 1668710 1991
CUI: C0036986
Disease: Shock, Traumatic
Shock, Traumatic
0.200 Therapeutic phenotype RGD Beneficial actions of BN 50739, a new PAF receptor antagonist, in murine traumatic shock. 2165204 1990
CUI: C0376618
Disease: Endotoxemia
Endotoxemia
0.200 Therapeutic phenotype RGD Platelet activating factor receptor antagonist improves survival and attenuates eicosanoid release in severe endotoxemia. 2178565 1990
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Therapeutic disease RGD Role of platelet activating factor in endotoxemic acute renal failure in the male rat. 2538527 1989
CUI: C0020649
Disease: Hypotension
Hypotension
0.200 Therapeutic phenotype RGD Platelet-activating factor (PAF) mediation of rat anaphylactic responses to soluble immune complexes. Studies with PAF receptor antagonist L-652,731. 3011900 1986
CUI: C0027947
Disease: Neutropenia
Neutropenia
0.200 Therapeutic disease RGD Platelet-activating factor (PAF) mediation of rat anaphylactic responses to soluble immune complexes. Studies with PAF receptor antagonist L-652,731. 3011900 1986
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Therapeutic disease RGD Effect of the platelet-activating factor antagonist BN 50739 and its diluents on mitochondrial respiration and membrane lipids during and following cerebral ischemia. 8158141 1994
CUI: C0155877
Disease: Allergic asthma
Allergic asthma
0.010 AlteredExpression disease BEFREE Using two-color immunofluorescence techniques and highly purified cell populations, it was not possible to detect surface PAFR protein or functional PAFR on resting and in vivo or in vitro activated T and B cells derived from nonallergic individuals or patients with allergic asthma. 8207248 1994
Other specified forms of pleural effusion, except tuberculous
0.200 Therapeutic disease RGD Interference of the PAF receptor antagonist, PCA 4248, with the rat pleurisy evoked by inflammatory mediators or allergen. 8395390 1993
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.050 AlteredExpression group BEFREE An elongated splice variant was identified in the 5'-untranslated region of the tissue-type PAF-R transcript (334 bp) in colonic epithelial crypts and tumors. 9603913 1998
CUI: C0026766
Disease: Multiple Organ Failure
Multiple Organ Failure
0.200 Therapeutic phenotype RGD Protective effects of a PAF receptor antagonist and a neutrophil elastase inhibitor on multiple organ failure induced by cerulein plus lipopolysaccharide in rats. 9750012 1998
CUI: C3665444
Disease: Neutrophilia (disorder)
Neutrophilia (disorder)
0.210 Therapeutic disease RGD Scorpion venom-induced neutrophilia is inhibited by a PAF receptor antagonist in the rat. 10770284 2000
CUI: C0151683
Disease: Neutrophilia (finding)
Neutrophilia (finding)
0.200 Therapeutic phenotype RGD Scorpion venom-induced neutrophilia is inhibited by a PAF receptor antagonist in the rat. 10770284 2000
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.020 AlteredExpression disease BEFREE Expression of platelet-activating factor receptor in human carotid atherosclerotic plaques: relevance to progression of atherosclerosis. 11085958 2000
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.020 AlteredExpression disease BEFREE Expression of platelet-activating factor receptor in human carotid atherosclerotic plaques: relevance to progression of atherosclerosis. 11085958 2000
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury
0.200 Therapeutic disease RGD Effects of the PAF receptor antagonist UK74505 on local and remote reperfusion injuries following ischaemia of the superior mesenteric artery in the rat. 11139461 2000
CUI: C0162557
Disease: Liver Failure, Acute
Liver Failure, Acute
0.200 Biomarker disease RGD Role of PAF in acute liver injury after extended hepatectomy: overexpression of PAF receptor mRNA in Kupffer cells. 11414308 2001
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.010 Biomarker group BEFREE Platelet-activating factor receptor (PAF-R) transcripts were analysed by reverse transcriptase-polymerase chain reaction in five human cancer cell lines derived from the breast (BT20, SKBR3 and T47D cells), the pancreas (Miapaca cells) and the bladder (5,637 cells) in order to confirm the existence of a splice variant of the PAF-R transcript 2. 12467527 2002
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.010 Biomarker group BEFREE Platelet-activating factor receptor (PAF-R) transcripts were analysed by reverse transcriptase-polymerase chain reaction in five human cancer cell lines derived from the breast (BT20, SKBR3 and T47D cells), the pancreas (Miapaca cells) and the bladder (5,637 cells) in order to confirm the existence of a splice variant of the PAF-R transcript 2. 12467527 2002
CUI: C0009763
Disease: Conjunctivitis
Conjunctivitis
0.200 Biomarker disease RGD Direct action of platelet activating factor (PAF) induces eosinophil accumulation and enhances expression of PAF receptors in conjunctivitis. 15735601 2005
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.010 GeneticVariation disease BEFREE These findings suggest that the PAFR gene missense mutation has a relation to the susceptibility for MS. 15748960 2005
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.010 GeneticVariation disease LHGDN These findings suggest that the PAFR gene missense mutation has a relation to the susceptibility for MS. 15748960 2005
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.020 Biomarker disease BEFREE Oxidized phospholipid: POVPC binds to platelet-activating-factor receptor on human macrophages. Implications in atherosclerosis. 16386258 2006
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.020 Biomarker disease BEFREE Oxidized phospholipid: POVPC binds to platelet-activating-factor receptor on human macrophages. Implications in atherosclerosis. 16386258 2006
CUI: C0266463
Disease: Lissencephaly
Lissencephaly
0.010 Biomarker disease BEFREE Finally, logistic regression showed that poor Wisconsin Card Sorting Test-Perseverative Errors performance was the only predictor of belonging to the positive lissencephaly critical region/platelet-activating-factor receptor group. 16549273 2006