In conclusion, the present study revealed that HCG22 inhibited BCa progression via the HuR/PTBP1 axis, opening new prospects for potent therapeutic regimens for BCa patients.
Accordingly, PTBP1 modulated AS of bladder cancer-related genes in cell lines and patient's specimens.<b>Conclusions:</b> PTBP1 expression correlates with disease progression, poor prognosis, and worse survival in patients with NMIBC.
These results thus indicate that the miR-145/KLF4/PTBP1/PKMs axis is one of the critical pathways that maintain the Warburg effect in BC carcinogenesis.
A Novel Combination RNAi toward Warburg Effect by Replacement with miR-145 and Silencing of PTBP1 Induces Apoptotic Cell Death in Bladder Cancer Cells.