Glioma
|
0.700 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
Glioma
|
0.700 |
GenomicAlterations
|
disease |
CGI |
|
|
|
Glioma
|
0.700 |
CausalMutation
|
disease |
CGI |
|
|
|
Glioma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Glioma cell growth inhibition following photochemical internalization enhanced non-viral PTEN gene transfection.
|
23018764 |
2012 |
Glioma
|
0.700 |
AlteredExpression
|
disease |
LHGDN |
PTEN gene expression was suppressed in the glioma, which is related to the clinical-pathological results.
|
17000554 |
2006 |
Glioma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
PTEN gene expression was suppressed in the glioma, which is related to the clinical-pathological results.
|
17000554 |
2006 |
Glioma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells.
|
19265662 |
2009 |
Glioma
|
0.700 |
Biomarker
|
disease |
BEFREE |
PTEN, an important negative regulator of the PI3K-Akt pathway, is also commonly mutated in glioma, leading to constitutive activation of Akt.
|
19549905 |
2009 |
Glioma
|
0.700 |
Biomarker
|
disease |
BEFREE |
PTEN status switches cell fate between premature senescence and apoptosis in glioma exposed to ionizing radiation.
|
21072054 |
2011 |
Glioma
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
PTEN suppresses SPARC-induced pMAPKAPK2 and inhibits SPARC-induced Ser78 HSP27 phosphorylation in glioma.
|
23382286 |
2013 |
Glioma
|
0.700 |
Biomarker
|
disease |
BEFREE |
PTEN loss and EGFR amplification were distributed in different glioma histological groups.
|
26957305 |
2017 |
Glioma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
MMAC1 coding-region mutations were observed in a number of glioma, prostate, kidney and breast carcinoma cell lines or tumour specimens.
|
9090379 |
1997 |
Glioma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A new tumor suppressor gene PTEN/MMAC1 was recently isolated at chromosome 10q23 and found to be inactivated by point mutation or homozygous deletion in glioma, prostate and breast cancer.
|
9671402 |
1998 |
Glioma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A novel tumor suppressor gene, PTEN/MMAC1, has been recently shown to be mutated in gliomas, breast, prostate, kidney cancers and melanomas.
|
9692547 |
1998 |
Glioma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Abnormal TUG1 expression was conducted in two glioma cells to analyze its regulation on miR-26a and PTEN using real-time PCR, western blot, and luciferase reporter assay.
|
27363339 |
2016 |
Glioma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Although the phosphatidylinositol 3-kinase to Akt to mammalian target of rapamycin (PI3K-Akt-mTOR) pathway promotes survival signaling, inhibitors of PI3K and mTOR induce minimal cell death in PTEN (phosphatase and tensin homolog deleted from chromosome 10) mutant glioma.
|
21062993 |
2010 |
Glioma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Among the many possible mechanisms underlying its pathogenesis, hyperactivation of the PI3K/Akt pathway is essential to the occurrence and development of glioma through the loss of PTEN or somatic activating mutations in PIK3CA.
|
30542720 |
2019 |
Glioma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
As expected, luciferase results verified the putative target site and also revealed the complementary binding between miR-19a and MEG3. miR-19a represses the expression of PTEN and promotes glioma cell proliferation, migration, and invasion.
|
28276316 |
2017 |
Glioma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Because PTEN negatively regulates on the downstream effects of phosphatidylinositol-3-kinase (PI3-K), we hypothesized that the loss of PTEN/MMAC1 and the activation of RAS may be largely equivalent because RAS is a known positive upstream regulator of PI3-K. We expanded our previous survey of PTEN/MMAC1 mutations and analyzed the RAS status of 53 cutaneous melanoma cell lines, 18 glioma cell lines, and 17 uncultured cutaneous melanoma metastasis.
|
10766161 |
2000 |
Glioma
|
0.700 |
Biomarker
|
disease |
BEFREE |
CD164 regulates proliferation and apoptosis by targeting PTEN in human glioma.
|
28259931 |
2017 |
Glioma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Co-administration of ABT-737 and SAHA induces apoptosis, mediated by Noxa upregulation, Bax activation and mitochondrial dysfunction in PTEN-intact malignant human glioma cell lines.
|
25139025 |
2014 |
Glioma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Combined evaluation by single clone and whole chromosome analysis plus 'moving average (MA) approach' enabled us to confirm most of the genetic abnormalities previously identified to be associated with glioma progression, including +1q32, +7, -10, -22q, PTEN and p16 loss, and to disclose new small genomic regions, some correlating with grade malignancy.
|
16247447 |
2006 |
Glioma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Consistent with this idea, several integrin alpha(V)beta(3)-expressing glioma cell lines with PTEN mutations and high levels of phospho-Akt (pAkt) were unaffected by exposure to an active fragment of tumstatin (T3), whereas alpha(V)beta(3)-expressing glioma cell lines with a functional PTEN/low levels of pAkt exhibited T3-induced growth suppression that could be bypassed by small interfering RNA-mediated suppression of PTEN, introduction of a constitutively expressed Akt, or introduction of the Akt and mTOR target eukaryotic translation initiation factor 4E.
|
17145879 |
2006 |
Glioma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Ethnicity-stratified subgroup analysis demonstrated that PTEN gene mutations were closely linked to poor prognosis in glioma among Americans (HR = 3.72, 95%CI = 1.72 ~ 5.73, P < 0.001), while similar correlations were not observed among populations in Sweden, Italy, and Malaysia (all P > 0.05).
|
24705863 |
2014 |
Glioma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Ethnicity-stratified subgroup analysis demonstrated that PTEN gene mutations were closely linked to poor prognosis in glioma among Americans (HR = 3.72, 95 % CI = 1.72∼5.73, P < 0.001), while similar correlations were not observed among populations in Sweden, Italy, and Malaysia (all P > 0.05).
|
26025112 |
2015 |