Glioma
|
0.700 |
Biomarker
|
disease |
BEFREE |
The ING4/PTEN double tumor suppressors mediated by adenovirus modified with RGD had a significantly synergistic antitumor effect on glioma.
|
28407709 |
2020 |
Glioma
|
0.700 |
Biomarker
|
disease |
BEFREE |
This symbiotic glioma-macrophage interplay provides therapeutic targets specifically for PTEN-deficient GBM.
|
31185211 |
2019 |
Glioma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
miR-21 may regulate the proliferation and apoptosis of human glioma cells by downregulating the expression of the PTEN protein, and miR-21 may represent a potential therapeutic target for the treatment of glioma.
|
28534371 |
2019 |
Glioma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Then, we also analyzed the impact of TERT promoter mutations, PTEN deletion, EGFR amplification and MGMT promoter methylation in diagnosis, prognosis and response to therapy in glioma molecular subgroup.
|
31623593 |
2019 |
Glioma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We modified an immune-competent, genetically-driven mouse glioma model (forced PDGF expression + PTEN loss) where a portion of the tumor burden is irradiated (PDGF) and another un-irradiated luciferase expressing tumor (PDGF+Luciferase) is used as a readout of the abscopal effect following systemic anti-PD-L1 immunotherapy.
|
31793634 |
2019 |
Glioma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The expression of miR-26a and PTEN in glioma was quantified and the interaction among miR-26a, PTEN and PI3K/Akt signaling pathway was examined.
|
31101062 |
2019 |
Glioma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair.
|
30827889 |
2019 |
Glioma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We did whole exome sequencing for 11 GBM-PN cases and found that the percentage of TP53, PIK3CA, PIK3R1, or PTEN mutation in our GBM-PN cases (72.7%, 27.3%, 27.3%, and 27.3% respectively) was much higher than that in cases in TCGA GBM 2008, TCGA GBM 2013, and TCGA lower-grade glioma databases.
|
30715630 |
2019 |
Glioma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
LINC01198 promotes proliferation and temozolomide resistance in a NEDD4-1-dependent manner, repressing PTEN expression in glioma.
|
31469661 |
2019 |
Glioma
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
FGFR2-mediated phosphorylation of PTEN at tyrosine 240 contributes to the radioresistance of glioma.
|
31025173 |
2019 |
Glioma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Among the many possible mechanisms underlying its pathogenesis, hyperactivation of the PI3K/Akt pathway is essential to the occurrence and development of glioma through the loss of PTEN or somatic activating mutations in PIK3CA.
|
30542720 |
2019 |
Glioma
|
0.700 |
Biomarker
|
disease |
BEFREE |
The promotion of PTEN promoted the function of anti‑miR‑494 on glioma cancer cell growth through Akt/mTOR pathway.
|
30365133 |
2019 |
Glioma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The U87 culture supernatant promoted the M2 phenotype of THP1 cells. miR-32 was upregulated and PTEN was downregulated in THP1 cells with the M2 phenotype in the glioma microenvironment.
|
31218569 |
2019 |
Glioma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Preclinical therapeutic efficacy of a novel blood-brain barrier-penetrant dual PI3K/mTOR inhibitor with preferential response in PI3K/PTEN mutant glioma.
|
28423515 |
2017 |
Glioma
|
0.700 |
Biomarker
|
disease |
BEFREE |
PTEN loss and EGFR amplification were distributed in different glioma histological groups.
|
26957305 |
2017 |
Glioma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Through comparative analyses of 286 cases of IDH-wildtype and IDH-mutant lower-grade glioma from a TCGA data set, we report that IDH-mutant gliomas have increased expression of tumor-suppressor genes (NF1, PTEN, and PIK3R1) and decreased expression of oncogenes(AKT2, ARAF, ERBB2, FGFR3, and PDGFRB) and glioma progression genes (FOXM1, IGFBP2, and WWTR1) compared with IDH-wildtype gliomas.
|
27852048 |
2017 |
Glioma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
As expected, luciferase results verified the putative target site and also revealed the complementary binding between miR-19a and MEG3. miR-19a represses the expression of PTEN and promotes glioma cell proliferation, migration, and invasion.
|
28276316 |
2017 |
Glioma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Meanwhile, genetic ablation of miR-92b could restore PTEN expression and inhibit glioma growth.
|
28337377 |
2017 |
Glioma
|
0.700 |
Biomarker
|
disease |
BEFREE |
CD164 regulates proliferation and apoptosis by targeting PTEN in human glioma.
|
28259931 |
2017 |
Glioma
|
0.700 |
Biomarker
|
disease |
BEFREE |
In the current study, we show that co-expression of PIKE-A and CDK4 in TP53/PTEN double knockout GBM mouse model additively shortens the latency of glioma onset and survival compared to overexpression of these genes alone.
|
28368413 |
2017 |
Glioma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
SALL4 suppresses PTEN expression to promote glioma cell proliferation via PI3K/AKT signaling pathway.
|
28887597 |
2017 |
Glioma
|
0.700 |
Biomarker
|
disease |
BEFREE |
LncRNA CASC2 Interacts With miR-181a to Modulate Glioma Growth and Resistance to TMZ Through PTEN Pathway.
|
28121023 |
2017 |
Glioma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In addition, miR‑216b regulated phosphatidylinositol 3,4,5‑trisphosphate 3‑phosphatase and dual‑specificity protein phosphatase PTEN/protein kinase B signaling pathways in glioma.
|
29152659 |
2017 |
Glioma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Tangeretin induces cell cycle arrest and apoptosis through upregulation of PTEN expression in glioma cells.
|
27261630 |
2016 |
Glioma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Abnormal TUG1 expression was conducted in two glioma cells to analyze its regulation on miR-26a and PTEN using real-time PCR, western blot, and luciferase reporter assay.
|
27363339 |
2016 |