Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0014544
Disease: Epilepsy
Epilepsy 		0.320 Biomarker disease BEFREE SLC4A10 is the third SLC4 base transporter family member to be implicated in human cognition and epilepsy. 18413482 2008
CUI: C0014544
Disease: Epilepsy
Epilepsy 		0.320 Biomarker disease BEFREE This second region comprises about 3 Mb and contains the candidate gene SLC4A10, providing further support for the potential role of this gene in epilepsy. 21204806 2010
CUI: C3714756
Disease: Intellectual Disability
Intellectual Disability 		0.310 Biomarker group BEFREE Disruption of sodium bicarbonate transporter SLC4A10 in a patient with complex partial epilepsy and mental retardation. 18413482 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.110 GeneticVariation disease BEFREE Based on conjunctional FDR < 0.05, we identified 2 loci shared between SCZ and ICV implicating genes FOXO3 (rs10457180) and ITIH4 (rs4687658), 2 loci shared between SCZ and hippocampal volume implicating SLC4A10 (rs4664442) and SPATS2L (rs1653290), and 2 loci shared between SCZ and volume of putamen implicating DCC (rs4632195) and DLG2 (rs11233632). 29136250 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.010 Biomarker disease BEFREE Six genes were identified as of interest for a follow-up, based on the strength of the association and based on the interest as potential candidate target for developing new treatment for depression: Solute Carrier Family 4 Member 10 (SLC4A10), Dipeptidyl Peptidase IV (DPP4), Dopamine Receptor D3 (DRD3), Zinc Finger Protein 80 (ZNF80), Nitric Oxide Synthase 2A (NOS2A) and Peroxisome Proliferator-Activated Receptor-Gamma, Coactivator 1, Alpha (PPARGC1A). 21630437 2011
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.010 Biomarker disease BEFREE Six genes were identified as of interest for a follow-up, based on the strength of the association and based on the interest as potential candidate target for developing new treatment for depression: Solute Carrier Family 4 Member 10 (SLC4A10), Dipeptidyl Peptidase IV (DPP4), Dopamine Receptor D3 (DRD3), Zinc Finger Protein 80 (ZNF80), Nitric Oxide Synthase 2A (NOS2A) and Peroxisome Proliferator-Activated Receptor-Gamma, Coactivator 1, Alpha (PPARGC1A). 21630437 2011
CUI: C0020255
Disease: Hydrocephalus
Hydrocephalus 		0.010 Biomarker disease BEFREE Deferoxamine and solute carrier family 4 member 10 small interfering RNA improved cognitive and motor functions at 21 to 28 days post GMH and reduced cerebrospinal fluid production as well as the degree of hydrocephalus at 28 days after GMH. 29386206 2018
CUI: C0025362
Disease: Mental Retardation
Mental Retardation 		0.010 Biomarker disease BEFREE Disruption of sodium bicarbonate transporter SLC4A10 in a patient with complex partial epilepsy and mental retardation. 18413482 2008
CUI: C0040517
Disease: Gilles de la Tourette syndrome
Gilles de la Tourette syndrome 		0.010 GeneticVariation disease BEFREE Finally, seven candidate disease genes were disrupted in five carriers with neurocognitive disabilities (SVOPL, SUSD1, TOX, NCALD, SLC4A10) and one XX-male carrier with Tourette syndrome (LYPD6, GPC5). 27862604 2017
CUI: C0085417
Disease: Epilepsy, Complex Partial
Epilepsy, Complex Partial 		0.010 Biomarker disease BEFREE Disruption of sodium bicarbonate transporter SLC4A10 in a patient with complex partial epilepsy and mental retardation. 18413482 2008
CUI: C0339573
Disease: Glaucoma, Primary Open Angle
Glaucoma, Primary Open Angle 		0.010 GeneticVariation disease BEFREE There was no association between common sequence variants in the AQP1 or SLC4A10 genes and POAG in the Caucasian population. 20101282 2010
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.010 Biomarker phenotype BEFREE Six genes were identified as of interest for a follow-up, based on the strength of the association and based on the interest as potential candidate target for developing new treatment for depression: Solute Carrier Family 4 Member 10 (SLC4A10), Dipeptidyl Peptidase IV (DPP4), Dopamine Receptor D3 (DRD3), Zinc Finger Protein 80 (ZNF80), Nitric Oxide Synthase 2A (NOS2A) and Peroxisome Proliferator-Activated Receptor-Gamma, Coactivator 1, Alpha (PPARGC1A). 21630437 2011
CUI: C0432475
Disease: XX males
XX males 		0.010 Biomarker disease BEFREE Finally, seven candidate disease genes were disrupted in five carriers with neurocognitive disabilities (SVOPL, SUSD1, TOX, NCALD, SLC4A10) and one XX-male carrier with Tourette syndrome (LYPD6, GPC5). 27862604 2017
CUI: C0740749
Disease: Chronic metabolic acidosis
Chronic metabolic acidosis 		0.010 AlteredExpression disease BEFREE The sodium-driven chloride/bicarbonate exchanger NDCBE in rat brain is upregulated by chronic metabolic acidosis. 21195699 2011
CUI: C0014544
Disease: Epilepsy
Epilepsy 		0.320 Therapeutic disease CTD_human Hence, Slc4a10 is a promising pharmacological target for the therapy of epilepsy or elevated intracranial pressure. 18165320 2008
CUI: C3714756
Disease: Intellectual Disability
Intellectual Disability 		0.310 Biomarker group CTD_human Disruption of sodium bicarbonate transporter SLC4A10 in a patient with complex partial epilepsy and mental retardation. 18413482 2008
CUI: C0009241
Disease: Cognition Disorders
Cognition Disorders 		0.300 Biomarker group CTD_human Disruption of sodium bicarbonate transporter SLC4A10 in a patient with complex partial epilepsy and mental retardation. 18413482 2008
CUI: C0020796
Disease: Profound Mental Retardation
Profound Mental Retardation 		0.300 Biomarker disease CTD_human Disruption of sodium bicarbonate transporter SLC4A10 in a patient with complex partial epilepsy and mental retardation. 18413482 2008
CUI: C0025363
Disease: Mental Retardation, Psychosocial
Mental Retardation, Psychosocial 		0.300 Biomarker phenotype CTD_human Disruption of sodium bicarbonate transporter SLC4A10 in a patient with complex partial epilepsy and mental retardation. 18413482 2008
CUI: C0085541
Disease: Epilepsy, Frontal Lobe
Epilepsy, Frontal Lobe 		0.300 Biomarker disease CTD_human Disruption of sodium bicarbonate transporter SLC4A10 in a patient with complex partial epilepsy and mental retardation. 18413482 2008
CUI: C0086237
Disease: Epilepsy, Cryptogenic
Epilepsy, Cryptogenic 		0.300 Therapeutic disease CTD_human Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability. 18165320 2008
CUI: C0151740
Disease: Intracranial Hypertension
Intracranial Hypertension 		0.300 Therapeutic disease CTD_human Hence, Slc4a10 is a promising pharmacological target for the therapy of epilepsy or elevated intracranial pressure. 18165320 2008
CUI: C0236018
Disease: Aura
Aura 		0.300 Therapeutic phenotype CTD_human Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability. 18165320 2008
CUI: C0393671
Disease: Frontal Epilepsy, Benign, Childhood
Frontal Epilepsy, Benign, Childhood 		0.300 Biomarker disease CTD_human Disruption of sodium bicarbonate transporter SLC4A10 in a patient with complex partial epilepsy and mental retardation. 18413482 2008
CUI: C0393683
Disease: Epilepsy, Supplementary Motor
Epilepsy, Supplementary Motor 		0.300 Biomarker disease CTD_human Disruption of sodium bicarbonate transporter SLC4A10 in a patient with complex partial epilepsy and mental retardation. 18413482 2008