PTGIS, prostaglandin I2 synthase, 5740

N. diseases: 70; N. variants: 11
Disease: Hypertensive disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.100 Biomarker group LHGDN Adenoassociated virus-mediated prostacyclin synthase expression prevents pulmonary arterial hypertension in rats. 17635855 2007
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.100 Biomarker group BEFREE AAV-PGIS gene transfer improves hypoxia-induced pulmonary hypertension in mice. 17904526 2007
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.100 Biomarker group BEFREE These results suggest that the genotypes for ITGA2, GCK, and PTGIS may prove reliable for the assessment of the genetic component of hypertension. 17070428 2006
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.100 Biomarker group BEFREE Gene transfer of hepatocyte growth factor with prostacyclin synthase in severe pulmonary hypertension of rats. 15541968 2004
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.100 GeneticVariation group LHGDN Splicing mutation of the prostacyclin synthase gene in a family associated with hypertension. 12751759 2003
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.100 GeneticVariation group LHGDN Association study between a novel single nucleotide polymorphism of the promoter region of the prostacyclin synthase gene and essential hypertension. 11924728 2002
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.100 GeneticVariation group BEFREE The purpose of this study was to locate possible mutations in the PGIS gene related to hypertension and cerebral infarction. 12372404 2002
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.100 GeneticVariation group LHGDN The purpose of this study was to locate possible mutations in the PGIS gene related to hypertension and cerebral infarction. 12372404 2002
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.100 Biomarker group BEFREE We investigated whether in vivo gene transfer of human prostacyclin synthase (PGIS) ameliorates monocrotaline (MCT)-induced pulmonary hypertension in rats. 11034952 2000
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.100 Biomarker group BEFREE Human prostacyclin synthase gene and hypertension : the Suita Study. 10577996 1999
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.100 AlteredExpression group BEFREE We hypothesized that selective pulmonary overexpression of PGIS may prevent the development of pulmonary hypertension. 10359560 1999