PTHLH, parathyroid hormone like hormone, 5744

N. diseases: 321; N. variants: 5
Disease: Leukemia, T-Cell ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.070 Biomarker disease BEFREE These findings demonstrate that PTHrP induced pathologic osteolysis in T-cell leukemia but did not increase the incidence of skeletal metastasis. 31592701 2020
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.070 Biomarker disease BEFREE These results suggest that PTHrP may act as a humoral factor and IL-1 may act as a local factor in bone metabolism of ATL patients. 11529470 2001
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.070 AlteredExpression disease BEFREE PTHrP is expressed at high levels in leukemia cells derived from ATL patients, as well as in asymptomatic HTLV-1 positive carriers. 7812198 1994
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.070 Biomarker disease BEFREE Although parathyroid hormone-related peptide (PTHRP) is produced by adult T cell leukemia (ATL) cells and causes hypercalcemia in ATL patients, very little is known about the regulation of PTHRP gene expression in the leukemic cells. 8099324 1993
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.070 AlteredExpression disease BEFREE These results suggest that the transcription of the human PTHRP gene is enhanced through a cAMP-dependent pathway by PGE1 and that PGE1, as well as interleukin 2, plays an important role in the overexpression of the human PTHRP gene in HTLV-I-infected T cells leading to the development of hypercalcemia in ATL patients. 8380405 1993
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.070 AlteredExpression disease BEFREE These observations might explain the general expression of the PTHrP gene in ATL patients and the high incidence of hypercalcemia in ATL. 2388034 1990
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.070 Biomarker disease BEFREE These results suggest that PTHrP plays an important role in developing the hypercalcemia frequently observed in ATL patients. 3148595 1988