MIR451A, microRNA 451a, 574411

N. diseases: 177; N. variants: 2
Disease: Osteosarcoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.070 Biomarker disease BEFREE MicroRNA-451a inhibits the growth and invasion of osteosarcoma cell lines through targeting tripartite motif-containing 66. 31434545 2019
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.070 AlteredExpression disease BEFREE The results showed that MiR-451 expression level was significantly reduced in the osteosarcoma compared with normal bone tissues. 28086136 2017
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.070 Biomarker disease BEFREE In conclusion, our data demonstrate that miR-451 may function as a potential suppressor of tumor growth, migration and angiogenesis in OS via down-regulating IL 6R, suggesting a promising therapeutic avenue for managing OS. 27908732 2017
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.070 AlteredExpression disease BEFREE Particularly, statistical analysis of primary human osteosarcoma indicated that decreased expression of miR-451 was correlated with metastasis and recurrence. 25391425 2015
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.070 AlteredExpression disease BEFREE In addition, miR-451 down-regulation more frequently occurred in osteosarcoma specimens with advanced clinical stage (P < 0.001), positive distant metastasis (P = 0.015), and poor response to neoadjuvant chemotherapy (P < 0.001). 25471786 2015
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.070 Biomarker disease BEFREE Therefore, miR-451-induced suppression of LRH-1 can be a novel therapy to treat osteosarcoma. 25869073 2015
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.070 AlteredExpression disease BEFREE In conclusion, miR-451 played a tumor-suppressing role through modulating the expression of PGE2 and CCND1, suggesting a novel target for the diagnosis and treatment of osteosarcoma. 24218283 2014