SLC12A5, solute carrier family 12 member 5, 57468

N. diseases: 135; N. variants: 20
Disease: Pain ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030193
Disease: Pain
Pain 		0.080 Biomarker phenotype BEFREE We investigated whether the increase of NKCC1 and KCC2 is associated with peripheral pain transmission in dorsal root ganglion neurons. 31719257 2020
CUI: C0030193
Disease: Pain
Pain 		0.080 Biomarker phenotype BEFREE These findings demonstrate that KCC2 downregulation contributes equally to pain hypersensitivity in males and females. 31315039 2019
CUI: C0030193
Disease: Pain
Pain 		0.080 AlteredExpression phenotype BEFREE Our results demonstrate that STEP61 is the molecular brake that is lost following KCC2-dependent disinhibition and that the decrease in STEP61 activity drives the potentiation of excitatory GluN2B NMDAR responses in rodent and human models of pathological pain. 31135041 2019
CUI: C0030193
Disease: Pain
Pain 		0.080 Biomarker phenotype BEFREE In addition, disruption of Cl<sup>-</sup> exporter KCC2 has an effect on synaptic inhibition, which may be involved in developing pain, epilepsy, and possibly some neuropsychiatric disorders. 31165006 2019
CUI: C0030193
Disease: Pain
Pain 		0.080 Biomarker phenotype BEFREE Furthermore, GAD65 and KCC2 were the possible downstream targets of HDAC2 in pain modulation pathways. 31024248 2019
CUI: C0030193
Disease: Pain
Pain 		0.080 AlteredExpression phenotype BEFREE The impaired KCC2 expression is a vital mechanism of many types of pathological pain. 29482000 2018
CUI: C0030193
Disease: Pain
Pain 		0.080 AlteredExpression phenotype BEFREE Drugs such as HDAC inhibitors that suppress the influences of persistent pain on the expression of KCC2 may serve as a novel analgesic. 27506893 2017
CUI: C0030193
Disease: Pain
Pain 		0.080 AlteredExpression phenotype BEFREE PRF increased histone acetylation and KCC2 expression, partially restored the GABA synaptic function, and relieved sensitized pain behavior. 27688312 2017