SLC12A5, solute carrier family 12 member 5, 57468

N. diseases: 135; N. variants: 20
Disease: Inflammatory pain ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0234251
Disease: Inflammatory pain
Inflammatory pain 		0.020 Biomarker phenotype BEFREE Here, we show that KCC2-dependent disinhibition is coupled to increased GluN2B-mediated synaptic NMDAR responses in a rodent model of inflammatory pain, with an associated downregulation of the tyrosine phosphatase STEP61. 31135041 2019
CUI: C0234251
Disease: Inflammatory pain
Inflammatory pain 		0.020 AlteredExpression phenotype BEFREE The main purpose of our study was to investigate the role of epigenetic modification on potassium-chloride co-transporter 2 (KCC2) gene expression in the persistence of inflammatory pain. 27506893 2017