|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, our present study indicated that miR-383 inhibits proliferation, migration and angiogenesis of GECs in vitro via VEGF/VEGFR2-mediated FAK and Src signaling pathways, which would draw growing attention to miR-383c as a potential therapeutical target of glioma.
|
27693218 |
2017 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, our results suggest that W2 suppresses cancer cell migration and invasion by inhibiting FAK/STAT3 signaling and STAT3 translocation to the nucleus in monomorphic malignant human glioma cells..
|
28498494 |
2017 |
|
Glioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
VEGFR2 inhibitor SU-1498, AKT inhibitor LY294002 and FAK inhibitor 14 (FAK inhibitor) blocked the Robo4 knockdown-mediated alteration in glioma angiogenesis in vitro.
|
25833462 |
2015 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, our data showed that overexpression of BRMS1 inhibited glioma cell migration and adhesion capacity compared with the control group through the Src-FAK pathway.
|
24879377 |
2014 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The application of recombinant VEGF165 stimulated migration in glioma and endothelial cells, which was associated with increased FAK phosphorylation at Tyr861, suggesting that the suppression of cell migration by carbon ion radiation could be via VEGF-activated FAK signaling.
|
24893038 |
2014 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In summary, our findings suggest that SOCS3 inactivation by promoter hypermethylation is mutually exclusive to EGFR activation in gliomas and preferentially promotes glioma cell invasion through STAT3 and FAK activation.
|
21590492 |
2011 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, 4910 and 5310 glioma xenograft tissue sections from mice treated with MMP-9 shRNA showed reduced expression of FAK/c-Myc and elevated MAD levels.
|
21855630 |
2011 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
L1 stimulation of human glioma cell motility correlates with FAK activation.
|
21373966 |
2011 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of Pyk2 stimulated glioma cell migration, whereas expression of FAK inhibited glioma cell migration and stimulated cell cycle progression.
|
15967096 |
2005 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
LHGDN |
These data suggest that FAK and Pyk2 function as important signaling effectors in gliomas and indicate that their differential regulation may be determining factors in the temporal development of proliferative or migrational phenotypes.
|
12651906 |
2003 |
|
Glioma
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Mutated focal adhesion kinase induces apoptosis in a human glioma cell line, T98G.
|
12054581 |
2002 |