PTK2, protein tyrosine kinase 2, 5747

N. diseases: 205; N. variants: 21
Disease: precancerous lesions ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0940937
Disease: precancerous lesions
precancerous lesions 		0.010 Biomarker phenotype BEFREE Targeting FAK by either RNAi or pharmacologic inhibitors effectively blocked cell growth, colony formation, and invasion into 3D collagen matrices.<b>Conclusions:</b> CTTN and FAK emerge as powerful predictors of laryngeal cancer risk and recurrence risk beyond histologic grading.<b>Impact:</b> Our work supports the applicability of IHC CTTN and FAK as complementary markers for risk stratification in patients with laryngeal precancerous lesions. 29654156 2018