Carcinoma, Ovarian Epithelial
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Accordingly, increased FAK tyrosine phosphorylation was observed within HGSOC patient tumors surviving neo-adjuvant chemotherapy.
|
31478830 |
2019 |
Carcinoma, Ovarian Epithelial
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, 1-CP-U had a profound inhibitory effect on adhesion, invasion and metastasis of EOC <i>in vitro</i> and suppressed intraperitoneal dissemination and cancer growth <i>in vivo</i> assay, which was associated with inhibition on the FAK pathway.
|
31290719 |
2019 |
Carcinoma, Ovarian Epithelial
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Finally, we showed that digitoxin inhibited FAK phosphorylation in SKOV3 but not PYK2 phosphorylation in monocytes, thus providing a molecular mechanism accounting for the observed differential anti-migratory effect.
|
29890142 |
2018 |
Carcinoma, Ovarian Epithelial
|
0.100 |
Biomarker
|
disease |
BEFREE |
Estrogen receptor modulators genistein, daidzein and ERB-041 inhibit cell migration, invasion, proliferation and sphere formation via modulation of FAK and PI3K/AKT signaling in ovarian cancer.
|
29743815 |
2018 |
Carcinoma, Ovarian Epithelial
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Berberine inhibits the chemotherapy-induced repopulation by suppressing the arachidonic acid metabolic pathway and phosphorylation of FAK in ovarian cancer.
|
28990249 |
2017 |
Carcinoma, Ovarian Epithelial
|
0.100 |
Biomarker
|
disease |
BEFREE |
Frequent Loss of NISCH Promotes Tumor Proliferation and Invasion in Ovarian Cancer via Inhibiting the FAK Signal Pathway.
|
25724667 |
2015 |
Carcinoma, Ovarian Epithelial
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Data from The Cancer Genome Atlas were used to correlate FAK gene copy number and expression levels in EOC specimens.
|
24755674 |
2014 |
Carcinoma, Ovarian Epithelial
|
0.100 |
Biomarker
|
disease |
BEFREE |
Focal adhesion kinase (FAK) is a cytoplasmic protein-tyrosine kinase located on chromosome 8q24.3 (gene is Ptk2), a site commonly amplified in serous ovarian cancer.
|
23275034 |
2013 |
Carcinoma, Ovarian Epithelial
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Adrenomedullin expression in epithelial ovarian cancers and promotes HO8910 cell migration associated with upregulating integrin α5β1 and phosphorylating FAK and paxillin.
|
22400488 |
2012 |
Carcinoma, Ovarian Epithelial
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Low expression of DLC1 and high expression of p-FAK Y397 were found in the 76 cases of EOC.
|
22272086 |
2011 |
Carcinoma, Ovarian Epithelial
|
0.100 |
Biomarker
|
disease |
BEFREE |
Dual targeting of EphA2 and FAK in ovarian carcinoma.
|
19395869 |
2009 |