|
Malignant neoplasm of endometrium
|
0.010 |
Biomarker
|
disease |
BEFREE |
All in all, our research was the first endeavor to study the underlying mechanism of CHL1-AS1 in EC and confirmed that CHL1-AS1 regulated EC progression via targeting the miR-6076/CHL1 axis, offering new insight into treating EC.
|
31736153 |
2020 |
|
Diabetic Neuropathies
|
0.010 |
Biomarker
|
group |
BEFREE |
We have previously reported mitoprotective potency of Sirtuin1 (Sirt1) in diabetic neuropathy (DN) via targeting mitochondrial dysfunction but its nuclear control over mitochondrial bioenergetics remains unknown.
|
31639451 |
2020 |
|
Neuralgia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Reversal of peripheral nerve injury-induced neuropathic pain and cognitive dysfunction via genetic and tomivosertib targeting of MNK.
|
31590180 |
2020 |
|
Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Krüppel-like factor 9 promotes neuroblastoma differentiation via targeting the sonic hedgehog signaling pathway.
|
31782614 |
2020 |
|
Squamous cell carcinoma of esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
miR-760 exerts an antioncogenic effect in esophageal squamous cell carcinoma by negatively driving fat metabolism via targeting c-Myc.
|
31709636 |
2020 |
|
Endometrial Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
All in all, our research was the first endeavor to study the underlying mechanism of CHL1-AS1 in EC and confirmed that CHL1-AS1 regulated EC progression via targeting the miR-6076/CHL1 axis, offering new insight into treating EC.
|
31736153 |
2020 |
|
Central neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Krüppel-like factor 9 promotes neuroblastoma differentiation via targeting the sonic hedgehog signaling pathway.
|
31782614 |
2020 |
|
Acute pneumonia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Long non-coding RNA SNHG16 promotes lipopolysaccharides-induced acute pneumonia in A549 cells via targeting miR-370-3p/IGF2 axis.
|
31841752 |
2020 |
|
Ischemic stroke
|
0.010 |
Biomarker
|
disease |
BEFREE |
Glimepiride shows comparable efficacy with glibenclamide in alleviating brain injury after ischemic stroke in mice, possibly via targeting the Sur1-Trpm4 channel.
|
31704276 |
2020 |
|
Childhood Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Krüppel-like factor 9 promotes neuroblastoma differentiation via targeting the sonic hedgehog signaling pathway.
|
31782614 |
2020 |
|
Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Caffeic acid and ellagic acid ameliorate adjuvant-induced arthritis in rats via targeting inflammatory signals, chitinase-3-like protein-1 and angiogenesis.
|
30562713 |
2019 |
|
Astrocytoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
These results suggest functional disruption of M2 via gene mutation or altered expression as a convergent pathway regulating astrocytoma transformation.
|
31420939 |
2019 |
|
Cardiovascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Respondents with or without the condition of interest (CVD-related comorbidities or hypoglycaemia) were compared via generalized linear models in terms of the outcome variables: (1) health-related quality of life (HRQoL), (2) work productivity and activity impairment, (3) healthcare resource utilization and (4) economic costs.
|
30685348 |
2019 |
|
Cognition Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
In this study, we investigated the neuroprotective effects of 1-Methylnicotinamide (MNA), known as the main metabolite of nicotinamide, on reducing lipopolysaccharide (LPS)-induced cognitive deficits via targeting neuroinflammation and neuronal apoptosis.
|
31639616 |
2019 |
|
Coronary Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results obtained in the present study demonstrated that miR-370 served an important role in regulating coronary atherosclerosis via targeting FOXO1.
|
30651771 |
2019 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, the results suggested that miR-154 participates in the development of IDD and its effects are mediated via targeting FGF14.
|
30825225 |
2019 |
|
Epilepsy, Temporal Lobe
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings suggest that loss of O-GlcNAc homeostasis in the kainate model and in human TLE can be reversed via targeting of O-GlcNAc related pathways.
|
30625365 |
2019 |
|
Glioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Long noncoding RNA CASC15 is upregulated in glioma and facilitates cell proliferation and metastasis via targeting miR-130b-3p.
|
31539135 |
2019 |
|
Hypercholesterolemia, Familial
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Via genetic counseling and clinical management of carriers, we were able to reclassify 51% of the study participants from having previously established nonspecific hypercholesterolemia to having FH and identify 32% who were completely unaware of harboring a high-risk disease-associated genetic variant.
|
30270359 |
2019 |
|
Hyperlipidemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Proteins related to DNA repair and energy metabolism were identified via protein interaction network analysis as molecular targets of EHM that play key roles in ameliorating hyperlipidaemia.
|
31545933 |
2019 |
|
Hypoglycemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Respondents with or without the condition of interest (CVD-related comorbidities or hypoglycaemia) were compared via generalized linear models in terms of the outcome variables: (1) health-related quality of life (HRQoL), (2) work productivity and activity impairment, (3) healthcare resource utilization and (4) economic costs.
|
30685348 |
2019 |
|
Multiple Myeloma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, tumor-specific methylation-mediated silencing of miR-340-5p is likely an early event in myelomagenesis with adverse survival impact, via targeting multiple oncogenes in MAPK signaling and apoptosis, thereby a tumor suppressive miRNA in myeloma.
|
31064412 |
2019 |
|
Nephroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The present study illustrates that miR-140-5p functions as a tumor suppressor in the occurrence and development of WT via targeting <i>TGFBR1</i>, which provides theoretical foundation for serving miR-140-5p as a new diagnosis marker even a therapeutic target for WT.
|
30863174 |
2019 |
|
Neurilemmoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
ASC expression was suppressed via promoter methylation in over 80% of the human schwannomas tested.
|
30977509 |
2019 |
|
Nicotine Dependence
|
0.010 |
Biomarker
|
disease |
BEFREE |
Reducing the activity of Hb-IP nAChRs, either volitionally during smoking cessation or inadvertently via receptor desensitization during nicotine intake, may be a key trigger of withdrawal in nicotine dependence.
|
30867261 |
2019 |