|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Curiously, two serine proteases within the S9 family encoded by genes located on chromosome 2 appear to have a role in asthma: CD26/dipeptidyl peptidase 4 (DPP4) and DPP10.
|
27561663 |
2019 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Initial association results were confirmed in many subsequent association studies but the functional role of DPP10 in asthma remains unclear.
|
29361513 |
2018 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The DPP10 level was significantly higher in sera from patients with AERD compared with patients with aspirin-tolerant asthma and control subjects (P = .021 and P < .001, respectively).
|
25592153 |
2015 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Overall, the contribution of rare variants to asthma susceptibility was predominantly due to noncoding variants in sequences flanking the exons, although nonsynonymous rare variants in DPP10 and in IL12RB1 were associated with asthma in African Americans and European Americans, respectively.
|
22325360 |
2012 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
A meta-analysis combining these 2 African-ancestry populations yielded 3 SNPs with a combined P value of less than 10(-5) in genes of potential biologic relevance to asthma and allergic disease: rs10515807, mapping to the alpha-1B-adrenergic receptor (ADRA1B) gene on chromosome 5q33 (3.57 x 10(-6)); rs6052761, mapping to the prion-related protein (PRNP) gene on chromosome 20pter-p12 (2.27 x 10(-6)); and rs1435879, mapping to the dipeptidyl peptidase 10 (DPP10) gene on chromosome 2q12.3-q14.2.
|
19910028 |
2010 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Gene-based analyses that included all available SNPs in each gene found associations (P < .05) with both phenotypes for several genes: neuronal growth regulator 1 (NEGR1); roundabout, axon guidance receptor, homolog 1 (ROBO1); diacylglycerol kinase, gamma (DGKG); Fas apoptotic inhibitory molecule 2 (FAIM2); fat mass and obesity associated (FTO); and carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 (CHST8) among the BMI GWAS genes; interleukin 1 receptor-like 1 / interleukin 18 receptor 1 (IL1RL1/IL18R1), dipeptidyl-peptidase 10 (DPP10), phosphodiesterase 4D (PDE4D), V-myb myeloblastosis viral oncogene homolog (MYB), PDE10A, IL33, and especially protein tyrosine phosphatase, receptor type D (PTPRD) among the asthma GWAS genes; and protein kinase C, alpha (PRKCA) among the BMI and asthma candidate genes.
|
20816195 |
2010 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Multimarker analysis identified TGFB1, IL1RL1, the gene encoding IL-18 receptor 1 (IL18R1), and DPP10 as the genes most significantly associated with asthma.
|
19910030 |
2010 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The evidence for ADAM33 and BHR and for an age-specific effect of two SNPs in DPP10 and asthma was weaker.
|
19996348 |
2010 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to assess the common PHF11 and DPP10 polymorphisms for associations to asthma and asthma-related traits in a Han Chinese population.
|
19672052 |
2010 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our study is the first one to provide additional evidence that supports the roles of DPP10 in influencing asthma or BHR in a Chinese population.
|
19951440 |
2009 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
These data suggest that DPP10 and ADAM33 influence asthma risk in the UK population.
|
19237393 |
2009 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
RGD |
Regulation of expression and function of dipeptidyl peptidase 4 (DP4), DP8/9, and DP10 in allergic responses of the lung in rats.
|
17967935 |
2008 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
In 2003, two novel genes relating to asthma were identified using this approach, PHF11 and DPP10, neither of which had previously been implicated in the pathobiology of either asthma or allergy.
|
14764626 |
2004 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
DPP10 encodes a homolog of dipeptidyl peptidases (DPPs) that cleave terminal dipeptides from cytokines and chemokines, and it presents a potential new target for asthma therapy.
|
14566338 |
2003 |