|
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Detection of the KIAA1549-BRAF fusion gene in cells forming microvascular proliferations in pilocytic astrocytoma.
|
31329636 |
2019 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The review of imaging features indicated that cyst formation is associated with the existence of KIAA1549-BRAF fusion in PA and GG and the lack of BRAF mutation in GG.
|
31147232 |
2019 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
KIAA1549-BRAF is the most frequently identified genetic mutation in sporadic pilocytic astrocytoma (PA), creating a fusion BRAF (f-BRAF) protein with increased BRAF activity.
|
30504064 |
2019 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
More recently, cases of PA with gangliocytic differentiation (PA-GD) have been described, and these cases are thus far restricted to those with the KIAA1549-BRAF fusion.
|
31147230 |
2019 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
BRAF-V600E mutations are most commonly found in pleomorphic xanthoastrocytoma, ganglioglioma, epithelioid glioblastoma, and gliomas diagnosed at a younger age; BRAF-KIAA1549 fusion is the most common BRAF alteration in pilocytic astrocytoma.
|
30265855 |
2018 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, KIAA1549-BRAF fusion gene was identified by fluorescence in situ hybridization (FISH), supporting for the diagnosis of PA.
|
29768357 |
2018 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
BRAF fusion involving the KIAA1549 gene is a hallmark of pilocytic astrocytoma, but it has also been recorded in rare cases of gangliogliomas, 1p/19q co-deleted oligodendroglial tumors, and it is also a common feature of disseminated oligodendroglial-like leptomeningeal neoplasm.
|
29802359 |
2018 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
KIAA1549-BRAF fusion is the most common genetic event in pilocytic astrocytoma (PA), and leads to activation of the mitogen activated protein kinase (MAPK) signaling pathway.
|
29141672 |
2017 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taken together, we have established the first patient-derived long term expandable PA cell line expressing the KIAA1549:BRAF-fusion suitable for preclinical drug testing.
|
28002790 |
2017 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A recurrent feature of PA is deregulation of the mitogen activated protein kinase (MAPK) pathway most often through KIAA1549-BRAF fusion, but also by other BRAF- or RAF1-gene fusions and point mutations (e.g.BRAFV600E).
|
28448514 |
2017 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Case 1 was likely a pilocytic astrocytoma (PA) with three deletions in 7q33q34 and an exon 15-9 KIAA1549-BRAF fusion.
|
25040262 |
2015 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In summary, we confirmed the high frequency of KIAA1549:BRAF fusion in PAs and its association with a better outcome.
|
26083571 |
2015 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The KIAA1549:BRAF fusion gene is considered a driver genetic event in pilocytic astrocytoma.
|
25382612 |
2015 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Activation of the MAP Kinase (MAPK) pathway caused by the BRAFV600E mutation or the KIAA1549-BRAF fusion has been reported in pediatric GG and PA, respectively.
|
25524464 |
2014 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The unique predilection of these tumors to form within the optic pathway and brainstem (NF1-PA) and cerebellum (sporadic PA) raises the possibility that gliomagenesis requires more than biallelic inactivation of the NF1 tumor suppressor gene or expression of the KIAA1549:BRAF transcript.
|
23624918 |
2014 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our study supports the notion that BRAF duplication is more typical of posterior fossa pilocytic astrocytoma and that molecular alterations other than KIAA1549 fusion may underlie MAPK pathway activation in pilocytic astrocytoma of the optic nerve.
|
23702730 |
2013 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The frequency of BRAF-KIAA1549 fusion transcripts is significantly lower in adult patients with pilocytic astrocytoma, weakening the sensitivity of this specific diagnostic marker in that age group.
|
21696415 |
2011 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The latest discovery involving the tandem duplication and fusion BRAF-KIAA1549 on chromosome 7q34 in pilocytic astrocytoma has drawn attention to the MAPK-ERK pathway and its potential chemotherapeutic manipulation.
|
20919607 |
2010 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma.
|
19363522 |
2009 |