TRIB3, tribbles pseudokinase 3, 57761

N. diseases: 104; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0577631
Disease: Carotid Atherosclerosis
Carotid Atherosclerosis 		0.020 GeneticVariation disease BEFREE The TRIB3 R84 allele especially predisposes to carotid atherosclerosis in part through the effects of abdominal obesity, hypertriglyceridemia, and insulin resistance. 19389818 2009
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.010 AlteredExpression disease BEFREE TRB3 protein levels were low in cells from normal cartilage but significantly increased in cells from OA cartilage. 19180501 2009
CUI: C0021655
Disease: Insulin Resistance
Insulin Resistance 		0.300 Biomarker phenotype CTD_human In our study population hepatic TRIB3 mRNA expression was associated with surrogate markers of insulin resistance. 20461355 2010
CUI: C0920563
Disease: Insulin Sensitivity
Insulin Sensitivity 		0.300 Biomarker phenotype CTD_human Aberrant hepatic TRIB3 gene expression in insulin-resistant obese humans. 20461355 2010
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.100 GeneticVariation disease BEFREE In sample 1 (n=791), the association between TRIB3 Q84R and impaired glucose regulation (IGR; defined as impaired fasting glucose and/or impaired glucose tolerance and/or type 2 diabetes by OGTT) and insulin sensitivity (ISI), and its interplay with early-phase insulin secretion (i.e. disposition index [DI]) were analysed. 20393693 2010
CUI: C0011847
Disease: Diabetes
Diabetes 		0.040 AlteredExpression disease BEFREE Animal studies have shown that Trib3 expression was higher in the fasting state and in animal models of diabetes, promoting hyperglycaemia presumably by increasing glucose production in the liver. 20461355 2010
CUI: C0011847
Disease: Diabetes
Diabetes 		0.040 Biomarker disease BEFREE TRIB3 acts as a nutrient sensor and could mediate the component of insulin resistance attributable to hyperglycemia (i.e., glucose toxicity) in diabetes. 19996382 2010
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.040 Biomarker group BEFREE TRIB3 acts as a nutrient sensor and could mediate the component of insulin resistance attributable to hyperglycemia (i.e., glucose toxicity) in diabetes. 19996382 2010
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.040 AlteredExpression group BEFREE Animal studies have shown that Trib3 expression was higher in the fasting state and in animal models of diabetes, promoting hyperglycaemia presumably by increasing glucose production in the liver. 20461355 2010
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.030 AlteredExpression disease BEFREE Animal studies have shown that Trib3 expression was higher in the fasting state and in animal models of diabetes, promoting hyperglycaemia presumably by increasing glucose production in the liver. 20461355 2010
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.030 Biomarker disease BEFREE TRIB3 acts as a nutrient sensor and could mediate the component of insulin resistance attributable to hyperglycemia (i.e., glucose toxicity) in diabetes. 19996382 2010
CUI: C0004763
Disease: Barrett Esophagus
Barrett Esophagus 		0.010 AlteredExpression disease BEFREE An integrative genomic approach in oesophageal cells identifies TRB3 as a bile acid responsive gene, downregulated in Barrett's oesophagus, which regulates NF-kappaB activation and cytokine levels. 20139130 2010
CUI: C0023418
Disease: leukemia
leukemia 		0.010 Biomarker disease BEFREE Increased Trib1 and Trib2 mRNA expression occurs in human myeloid leukemia and induces acute myeloid leukemia in mice, whereas Trib3 has not been associated with leukemia. 20410507 2010
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.010 Biomarker disease BEFREE Increased Trib1 and Trib2 mRNA expression occurs in human myeloid leukemia and induces acute myeloid leukemia in mice, whereas Trib3 has not been associated with leukemia. 20410507 2010
CUI: C0023470
Disease: Myeloid Leukemia
Myeloid Leukemia 		0.010 AlteredExpression disease BEFREE Increased Trib1 and Trib2 mRNA expression occurs in human myeloid leukemia and induces acute myeloid leukemia in mice, whereas Trib3 has not been associated with leukemia. 20410507 2010
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.010 Biomarker disease BEFREE Increased Trib1 and Trib2 mRNA expression occurs in human myeloid leukemia and induces acute myeloid leukemia in mice, whereas Trib3 has not been associated with leukemia. 20410507 2010
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE Furthermore, knockdown of endogenous TRB3 expression inhibited the migration and invasion of tumor cells in vitro, which were associated with an increase in the expression of E-cadherin and a decrease in the expression of Twist-1 and Snail, two master regulators of epithelial-to-mesenchymal transition, suggesting a crucial role for TRB3 in maintaining the mesenchymal status of tumor cells. 21896644 2011
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE TRB3 overexpression was closely correlated with tumor pathological T stage, lymph node metastasis and tumor recurrence. 21821462 2011
CUI: C0582591
Disease: Processing speed
Processing speed 		0.100 GeneticVariation phenotype GWASCAT Whole genome association scan for genetic polymorphisms influencing information processing speed. 21130836 2011
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.080 AlteredExpression disease BEFREE Furthermore, we studied TRIB3 expression regulation in cell lines, xenografts tissues and human breast cancer material using Reverse transcriptase, quantitative polymerase chain reaction (RT-qPCR) and immunohistochemical staining. 21864376 2011
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.080 AlteredExpression disease BEFREE We validated our earlier finding that high TRIB3 mRNA denotes a poor prognosis, but found that high TRIB3 protein levels were associated with a good prognosis in breast cancer patients. 21704407 2011
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.080 AlteredExpression disease BEFREE We validated our earlier finding that high TRIB3 mRNA denotes a poor prognosis, but found that high TRIB3 protein levels were associated with a good prognosis in breast cancer patients. 21704407 2011
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.080 AlteredExpression disease BEFREE Furthermore, we studied TRIB3 expression regulation in cell lines, xenografts tissues and human breast cancer material using Reverse transcriptase, quantitative polymerase chain reaction (RT-qPCR) and immunohistochemical staining. 21864376 2011
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.060 Biomarker phenotype BEFREE TRB3 interacts with SMAD3 promoting tumor cell migration and invasion. 21896644 2011
CUI: C0028754
Disease: Obesity
Obesity 		0.060 GeneticVariation disease BEFREE TRB3 Q84R polymorphism is associated with obesity and especially glucose metabolism and not associated with polycystic ovary syndrome because of compositional characteristics of phenotype in Chinese PCOS women. 21492415 2011