TRIB3, tribbles pseudokinase 3, 57761

N. diseases: 104; N. variants: 5
Disease: Diabetes ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011847
Disease: Diabetes
Diabetes 		0.040 Biomarker disease BEFREE In conclusion, TRIB3 has a pathophysiological role in diabetes and a physiological role in metabolism. 27207527 2016
CUI: C0011847
Disease: Diabetes
Diabetes 		0.040 GeneticVariation disease BEFREE The gain-of-function Q84R polymorphism in TRIB3 is associated with increased risk of diabetes and atherosclerosis. 26855171 2016
CUI: C0011847
Disease: Diabetes
Diabetes 		0.040 AlteredExpression disease BEFREE Animal studies have shown that Trib3 expression was higher in the fasting state and in animal models of diabetes, promoting hyperglycaemia presumably by increasing glucose production in the liver. 20461355 2010
CUI: C0011847
Disease: Diabetes
Diabetes 		0.040 Biomarker disease BEFREE TRIB3 acts as a nutrient sensor and could mediate the component of insulin resistance attributable to hyperglycemia (i.e., glucose toxicity) in diabetes. 19996382 2010