Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.320 Biomarker disease BEFREE PTPRS is the most commonly mutated receptor tyrosine phosphatase in colorectal cancer (CRC). 31827720 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.320 GeneticVariation disease BEFREE Native mutations in PTPRS, present in ~10% of CRC, may reduce its phosphatase activity while increasing ERK activation and downstream transcriptional signaling. 29915291 2018
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.320 GeneticVariation disease UNIPROT
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.100 GeneticVariation disease GWASCAT Radiogenomics Consortium Genome-Wide Association Study Meta-Analysis of Late Toxicity After Prostate Cancer Radiotherapy. 31095341 2020
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.020 Biomarker disease BEFREE We will focus on the PTPRS (encoding PTPsigma) gene and discuss its and other apical junction complex proteins' role in the pathogenesis of UC. 18598228 2008
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.020 GeneticVariation disease LHGDN We propose that polymorphisms in the human PTPRS gene lead to ulcerative colitis. 17614280 2007
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.020 GeneticVariation disease BEFREE We propose that polymorphisms in the human PTPRS gene lead to ulcerative colitis. 17614280 2007
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.010 Biomarker phenotype BEFREE PTPRs (both grades II and III) showed an aggressive histological transformation and also intraparenchymal metastasis. 31085866 2019
CUI: C1301363
Disease: Blastic plasmacytoid dendritic cell neoplasm
Blastic plasmacytoid dendritic cell neoplasm 		0.010 AlteredExpression disease BEFREE Along with the high levels of PTPRS and dendritic nature of the tumor cells, these findings suggest a possible pre-inflammatory context of this disease, in which BPDCN features nonactivated pDCs. 31811114 2019
CUI: C0028754
Disease: Obesity
Obesity 		0.010 Biomarker disease BEFREE Moreover, the DNA methylation levels of VIPR2, GRIN2D, ADCYAP1R1, PER3 and PTPRS regions correlated with the obesity trait. 28614626 2018
CUI: C0031941
Disease: Pineal Gland Neoplasm
Pineal Gland Neoplasm 		0.010 Biomarker disease BEFREE PTPRs are extremely rare in children, and immunohistochemistry is needed to differentiate them from other pineal tumors. 29906576 2018
CUI: C2362324
Disease: Pediatric Obesity
Pediatric Obesity 		0.010 PosttranslationalModification disease BEFREE PTPRS and PER3 methylation levels are associated with childhood obesity: results from a genome-wide methylation analysis. 28614626 2018
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 		0.010 Biomarker group BEFREE Protein tyrosine phosphatase (PTP)σ (PTPRS) was shown previously to be associated with susceptibility to inflammatory bowel disease (IBD). 24385580 2014
CUI: C0009319
Disease: Colitis
Colitis 		0.010 Biomarker disease BEFREE Here, we show that receptor protein-tyrosine phosphatase sigma (PTPRS-encoding PTPsigma) knockout mice spontaneously develop mild colitis that becomes severe when challenged with two known inducers of colitis. 17614280 2007
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.010 Biomarker disease LHGDN Genetic variation in receptor protein tyrosine phosphatase sigma is associated with type 2 diabetes in Swedish Caucasians. 17893260 2007
CUI: C0014474
Disease: Ependymoma
Ependymoma 		0.010 Biomarker disease BEFREE PTPRs, classified with chordoid glioma and separately from ependymomas, showed high expression of SPEDF, KRT18, and genes encoding proteins reported to be expressed in the subcommissural organ, namely ZFH4, RFX3, TTR, and CGRP. 16825954 2006