Herpes Simplex Infections
|
0.400 |
Biomarker
|
group |
BEFREE |
Furthermore, to investigate the therapeutic effects of nectin-1Ig, which can neutralize HSVs in vitro against ocular disease, transgenic mouse serum containing nectin-1Ig was dropped into the eyes of wild-type mice after HSV infection.
|
30575982 |
2019 |
Herpes Simplex Infections
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We also found that human erythroleukemia K562 cells, which are commonly used as susceptible targets to assess NK cell cytotoxicity did not express nectin-1 on their surface and were resistant to HSV infection.
|
30759143 |
2019 |
Herpes Simplex Infections
|
0.400 |
Biomarker
|
group |
BEFREE |
Here, we examined whether Cbl mediates the removal of the herpes simplex virus 1 (HSV-1) entry receptor Nectin-1 from the surface of infected cells.
|
28381567 |
2017 |
Herpes Simplex Infections
|
0.400 |
Biomarker
|
group |
BEFREE |
Herpesvirus entry mediator A (HVEM), nectin-1 and nectin-2 are cellular receptors of glycoprotein D (gD) of herpes simplex virus type-2 (HSV-2).
|
28671524 |
2017 |
Herpes Simplex Infections
|
0.400 |
Biomarker
|
group |
BEFREE |
Previous studies focused on the herpes simplex virus (HSV) of the Simplexvirus genus, for which both the free gD structure and the gD/nectin-1 complex structure were reported at high resolutions.
|
28542478 |
2017 |
Herpes Simplex Infections
|
0.400 |
Biomarker
|
group |
BEFREE |
Herpes simplex virus (HSV) uses the cell adhesion molecule nectin-1 as a receptor to enter neurons and epithelial cells.
|
27723487 |
2016 |
Herpes Simplex Infections
|
0.400 |
Biomarker
|
group |
BEFREE |
Herpes simplex virus (HSV) enters cells by means of four essential glycoproteins - gD, gH/gL, gB, activated in a cascade fashion by gD binding to one of its receptors, nectin1 and HVEM.
|
25996983 |
2015 |
Herpes Simplex Infections
|
0.400 |
Biomarker
|
group |
BEFREE |
The cellular proteins nectin-1 and herpesvirus entry mediator (HVEM) can both mediate the entry of herpes simplex virus 1 (HSV-1).
|
26136572 |
2015 |
Herpes Simplex Infections
|
0.400 |
Biomarker
|
group |
BEFREE |
Nectin-1 is a cell surface herpes simplex virus type 1 (HSV-1) receptor that also forms a component of intercellular adherens junctions, which are typically disrupted in EMT.
|
24568312 |
2014 |
Herpes Simplex Infections
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Additionally, immunofluorescence assays confirm that HSV infection decreases nectin-1 expression.
|
25414835 |
2014 |
Herpes Simplex Infections
|
0.400 |
Biomarker
|
group |
BEFREE |
Induction of conformational changes at the N-terminus of herpes simplex virus glycoprotein D upon binding to HVEM and nectin-1.
|
24314649 |
2014 |
Herpes Simplex Infections
|
0.400 |
Biomarker
|
group |
BEFREE |
Nectin-1-specific entry of herpes simplex virus 1 is sufficient for infection of the cornea and viral spread to the trigeminal ganglia.
|
23213272 |
2012 |
Herpes Simplex Infections
|
0.400 |
Biomarker
|
group |
BEFREE |
αVβ3-integrin relocalizes nectin1 and routes herpes simplex virus to lipid rafts.
|
22171266 |
2012 |
Herpes Simplex Infections
|
0.400 |
Biomarker
|
group |
BEFREE |
Herpes simplex virus (HSV) entry into cells is triggered by the binding of envelope glycoprotein D (gD) to a specific receptor, such as nectin-1 or herpesvirus entry mediator (HVEM), resulting in activation of the fusion effectors gB and gH and virus penetration.
|
20861246 |
2010 |
Herpes Simplex Infections
|
0.400 |
Biomarker
|
group |
BEFREE |
Either herpesvirus entry mediator (HVEM, TNFRSF14) or nectin-1 (PVRL1) is sufficient for herpes simplex virus (HSV) infection of cultured cells.
|
18005714 |
2007 |
Herpes Simplex Infections
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Cell lines with varying nectin-1 expression showed corresponding sensitivity to NV1023 therapy in vivo.
|
17164781 |
2007 |
Herpes Simplex Infections
|
0.400 |
Biomarker
|
group |
LHGDN |
Access to nectin favors herpes simplex virus infection at the apical surface of polarized human epithelial cells.
|
17005657 |
2006 |
Herpes Simplex Infections
|
0.400 |
Biomarker
|
group |
BEFREE |
The relative usage of HVEM and nectin-1 during HSV infection in vivo is not known.
|
15110526 |
2004 |
Herpes Simplex Infections
|
0.400 |
Biomarker
|
group |
LHGDN |
Herpes simplex virus (HSV) entry requires the interaction of glycoprotein D (gD) with a cellular receptor such as herpesvirus entry mediator (HVEM or HveA) or nectin-1 (HveC).
|
12915568 |
2003 |
Herpes Simplex Infections
|
0.400 |
Biomarker
|
group |
BEFREE |
Effects of herpes simplex virus on structure and function of nectin-1/HveC.
|
11836420 |
2002 |
Herpes Simplex Infections
|
0.400 |
Biomarker
|
group |
BEFREE |
The cDNA has the same ectodomain as nectin1alpha and nectin1beta, the two known transmembrane isoforms that serve as receptors for herpes simplex virus (HSV) entry into human cell lines (nectin1alpha and nectin1beta, also called PRR1-HveC and HIgR, respectively).
|
11356977 |
2001 |
Herpes Simplex Infections
|
0.400 |
Biomarker
|
group |
BEFREE |
Chimeric nectin1-poliovirus receptor molecules identify a nectin1 region functional in herpes simplex virus entry.
|
11483743 |
2001 |
Herpes Simplex Infections
|
0.400 |
Biomarker
|
group |
CTD_human |
Cell-to-cell spread of wild-type herpes simplex virus type 1, but not of syncytial strains, is mediated by the immunoglobulin-like receptors that mediate virion entry, nectin1 (PRR1/HveC/HIgR) and nectin2 (PRR2/HveB).
|
10729168 |
2000 |