DLGAP3, DLG associated protein 3, 58512

N. diseases: 18; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028768
Disease: Obsessive-Compulsive Disorder
Obsessive-Compulsive Disorder 		0.080 Biomarker disease BEFREE The Sapap3-KO model is thus a useful tool for future mechanistic studies to determine how mPFC hyperactivity contributes to OCD-relevant cognitive dysfunction. 30587851 2019
CUI: C0028768
Disease: Obsessive-Compulsive Disorder
Obsessive-Compulsive Disorder 		0.080 GeneticVariation disease BEFREE Behavioral flexibility in a mouse model for obsessive-compulsive disorder: Impaired Pavlovian reversal learning in SAPAP3 mutants. 30688005 2019
CUI: C0028768
Disease: Obsessive-Compulsive Disorder
Obsessive-Compulsive Disorder 		0.080 Biomarker disease BEFREE In conclusion, only Sapap3-KO mice developed behavior that was fully insensitive to reward devaluation, suggesting that pathological habits in OCD patients are recapitulated in the present Sapap3-KO mouse model. 31427755 2019
CUI: C0028768
Disease: Obsessive-Compulsive Disorder
Obsessive-Compulsive Disorder 		0.080 GeneticVariation disease BEFREE Lateral orbitofrontal dysfunction in the Sapap3 knockout mouse model of obsessive–compulsive disorder 30403026 2019
CUI: C0028768
Disease: Obsessive-Compulsive Disorder
Obsessive-Compulsive Disorder 		0.080 Biomarker disease BEFREE These data provide evidence of monoaminergic dysregulation in a translational model of OCD symptoms and are consistent with aberrant cortical and striatal serotonin and dopamine release/metabolism in SAPAP-3 KO mice. 29352023 2018
CUI: C0028768
Disease: Obsessive-Compulsive Disorder
Obsessive-Compulsive Disorder 		0.080 Biomarker disease BEFREE Loss of SAPAP3 leads to obsessive-compulsive disorder (OCD)-like behaviors due to alterations in metabotropic glutamate receptor (mGluR) signaling. 29908232 2018
CUI: C0028768
Disease: Obsessive-Compulsive Disorder
Obsessive-Compulsive Disorder 		0.080 AlteredExpression disease BEFREE SAP90/PSD95-associated protein 3 (SAPAP3/DLGAP3) is a post-synaptic scaffolding protein that is highly expressed in glutamatergic synapses in the striatum and has recently been investigated as a candidate gene in both OCD and GD studies. 21184590 2011
CUI: C0028768
Disease: Obsessive-Compulsive Disorder
Obsessive-Compulsive Disorder 		0.080 GeneticVariation disease BEFREE In the current study, we sought to determine whether variation within the human Sapap3 gene was associated with grooming disorders (GDs: pathologic nail biting, pathologic skin picking, and/or trichotillomania) and/or obsessive-compulsive disorder (OCD) in 383 families thoroughly phenotyped for OCD genetic studies. 19051237 2009
CUI: C0003467
Disease: Anxiety
Anxiety 		0.020 Biomarker disease BEFREE Similar to OCD patients, SAPAP3 knockout mice 3 (SAPAP3<sup>-/-</sup> ) exhibit compulsive behavior (grooming), anxiety and dysregulated cortical-striatal function. 30688005 2019
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.020 Biomarker group BEFREE Similar to OCD patients, SAPAP3 knockout mice 3 (SAPAP3<sup>-/-</sup> ) exhibit compulsive behavior (grooming), anxiety and dysregulated cortical-striatal function. 30688005 2019
CUI: C0600104
Disease: Obsessive compulsive behavior
Obsessive compulsive behavior 		0.020 AlteredExpression disease BEFREE Impaired instrumental reversal learning is associated with increased medial prefrontal cortex activity in Sapap3 knockout mouse model of compulsive behavior. 30587851 2019
CUI: C0600104
Disease: Obsessive compulsive behavior
Obsessive compulsive behavior 		0.020 Biomarker disease BEFREE Similar to OCD patients, SAPAP3 knockout mice 3 (SAPAP3<sup>-/-</sup> ) exhibit compulsive behavior (grooming), anxiety and dysregulated cortical-striatal function. 30688005 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.020 Biomarker disease BEFREE Exonic resequencing of the DLGAP3 gene as a candidate gene for schizophrenia. 23414653 2013
CUI: C0003467
Disease: Anxiety
Anxiety 		0.020 Biomarker disease BEFREE In two of the models, the Sapap3-deficient and the Slitrk5-deficient mice, the abnormal grooming behaviors are associated with enhanced anxiety and these pathological behaviors can be curtailed with subchronic administration of a selective serotonin reuptake inhibitor, suggesting the predictive validity of such models. 21386675 2011
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.020 Biomarker group BEFREE In two of the models, the Sapap3-deficient and the Slitrk5-deficient mice, the abnormal grooming behaviors are associated with enhanced anxiety and these pathological behaviors can be curtailed with subchronic administration of a selective serotonin reuptake inhibitor, suggesting the predictive validity of such models. 21386675 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.020 Biomarker disease BEFREE This study provides suggestive evidence that DLGAP3 and its interactive effect with SLC1A1 might be involved in susceptibility to developing OC symptoms in schizophrenia patients receiving AAP treatment. 21990008 2011
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.010 Biomarker disease BEFREE The Sapap3-KO model is thus a useful tool for future mechanistic studies to determine how mPFC hyperactivity contributes to OCD-relevant cognitive dysfunction. 30587851 2019
CUI: C0424295
Disease: Hyperactive behavior
Hyperactive behavior 		0.010 Biomarker phenotype BEFREE The Sapap3-KO model is thus a useful tool for future mechanistic studies to determine how mPFC hyperactivity contributes to OCD-relevant cognitive dysfunction. 30587851 2019
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.010 Biomarker disease BEFREE However, Kaplan‑Meier plots demonstrated that the expression of all DLGAPs, except for DLGAP3, was correlated with patient prognosis; DLGAP4 was consistently associated with GC. 30365066 2018
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.010 Biomarker phenotype BEFREE Also, cell polarity-related genes PARD3, PRKCI and DLGAP3, and autophagy-related genes ULK1 and ULK2 genes are considered to play crucial roles in tumorigenesis. 28844109 2018
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.010 Biomarker disease BEFREE However, Kaplan‑Meier plots demonstrated that the expression of all DLGAPs, except for DLGAP3, was correlated with patient prognosis; DLGAP4 was consistently associated with GC. 30365066 2018
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.010 Biomarker disease BEFREE The DEGs such as SYN1, GRIN1, GRIN2D and DLGAP3 may become promising candidate genes for PD. 26269422 2016
CUI: C0040517
Disease: Gilles de la Tourette syndrome
Gilles de la Tourette syndrome 		0.010 Biomarker disease BEFREE Although none of these results remained significant after correction for multiple hypothesis testing, DLGAP3 remains a promising candidate gene for TS. 21184590 2011
CUI: C0009595
Disease: Obsessive-Compulsive Personality
Obsessive-Compulsive Personality 		0.010 Biomarker disease BEFREE Sapap3 and pathological grooming in humans: Results from the OCD collaborative genetics study. 19051237 2009
CUI: C0029421
Disease: Osteochondritis Dissecans
Osteochondritis Dissecans 		0.010 Biomarker disease BEFREE Sapap3 and pathological grooming in humans: Results from the OCD collaborative genetics study. 19051237 2009