DLGAP3, DLG associated protein 3, 58512

N. diseases: 18; N. variants: 6
Disease: Anxiety ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003467
Disease: Anxiety
Anxiety 		0.020 Biomarker disease BEFREE Similar to OCD patients, SAPAP3 knockout mice 3 (SAPAP3<sup>-/-</sup> ) exhibit compulsive behavior (grooming), anxiety and dysregulated cortical-striatal function. 30688005 2019
CUI: C0003467
Disease: Anxiety
Anxiety 		0.020 Biomarker disease BEFREE In two of the models, the Sapap3-deficient and the Slitrk5-deficient mice, the abnormal grooming behaviors are associated with enhanced anxiety and these pathological behaviors can be curtailed with subchronic administration of a selective serotonin reuptake inhibitor, suggesting the predictive validity of such models. 21386675 2011