Disease: Addictive Behavior ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0085281
Disease: Addictive Behavior
Addictive Behavior 		0.030 Biomarker phenotype BEFREE We found that RAF node knockdown best differentiated <i>KRAS</i> mutant and <i>KRAS</i> WT cancer cells, suggesting RAF kinases are key oncoeffectors for <i>KRAS</i> addiction. 30709910 2019
CUI: C0085281
Disease: Addictive Behavior
Addictive Behavior 		0.030 Biomarker phenotype BEFREE These results reveal specific and compensatory functions for BRAF and CRAF and highlight an addiction to RAF signalling in NRAS-driven melanoma. 28497782 2017
CUI: C0085281
Disease: Addictive Behavior
Addictive Behavior 		0.030 AlteredExpression phenotype BEFREE Finally, we demonstrated that vemurafenib-resistant cells maintain their addiction to the MAPK pathway, and inhibition of MEK or pan-RAF activities is an effective therapeutic strategy to overcome acquired-resistance to vemurafenib. 22730329 2012