Diffuse Large B-Cell Lymphoma
|
0.310 |
Biomarker
|
disease |
CTD_human |
We have reported that ON 01910.Na (rigosertib), a multikinase inhibitor, is selectively cytotoxic for DLBCL and induces more hyperphosphorylation and sumoylation of Ran GTPase-activating protein 1 (RanGAP1) in DLBCL cells than in non-neoplastic lymphoblastoid cell line.
|
27150054 |
2016 |
Diffuse Large B-Cell Lymphoma
|
0.310 |
Biomarker
|
disease |
BEFREE |
Furthermore, ON 01910.Na (Estybon), a multikinase inhibitor induced cell death, mitotic cell arrest, and hyperphosphorylation of RanGAP1 in DLBCL cell lines but no effects in normal B and T cells.
|
24223200 |
2013 |
Sciatic Neuropathy
|
0.200 |
Biomarker
|
disease |
RGD |
Localized regulation of axonal RanGTPase controls retrograde injury signaling in peripheral nerve.
|
18667152 |
2008 |
Lymphocyte Count measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes.
|
22286170 |
2012 |
Myotonic Dystrophy
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The concept of segregation distortion, where there is preferential transmission of the larger allele at the DM locus, has been put forward to explain partially the maintenance of DM in the population.
|
9863607 |
1998 |
Myotonic Dystrophy
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Dynamic balance of segregation distortion and selection maintains normal allele sizes at the myotonic dystrophy locus.
|
9401353 |
1998 |
Myotonic Dystrophy
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
This suggests that any greater amount of segregation distortion at the myotonic dystrophy locus must result from events following sperm ejaculation.
|
8808606 |
1996 |
Myotonic Dystrophy
|
0.040 |
Biomarker
|
disease |
BEFREE |
Segregation distortion of the CTG repeats at the myotonic dystrophy locus.
|
8659513 |
1996 |
Myeloid Leukemia, Chronic
|
0.020 |
Biomarker
|
disease |
BEFREE |
Correction: MicroRNA-1301-Mediated RanGAP1 Downregulation Induces BCR-ABL Nuclear Entrapment to Enhance Imatinib Efficacy in Chronic Myeloid Leukemia Cells.
|
28267803 |
2019 |
Myeloid Leukemia, Chronic
|
0.020 |
Biomarker
|
disease |
BEFREE |
Altogether, we demonstrated that RanGAP1 downregulation can mediate BCR-ABL nuclear entrapment to activate P73-dependent apoptosis pathway which is a novel strategy for improving current IM treatment for CML.
|
27228340 |
2016 |
leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
RanGAP1 was also highly expressed in other B-cell lymphomas (BCL, n = 180) with brisk mitotic activity (B-lymphoblastic lymphoma/leukemia: 93%, and Burkitt lymphoma: 95%) or cell-cycle dysregulation (mantle cell lymphoma: 83%, and Hodgkin's lymphoma 91%).
|
24223200 |
2013 |
Childhood Leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
RanGAP1 was also highly expressed in other B-cell lymphomas (BCL, n = 180) with brisk mitotic activity (B-lymphoblastic lymphoma/leukemia: 93%, and Burkitt lymphoma: 95%) or cell-cycle dysregulation (mantle cell lymphoma: 83%, and Hodgkin's lymphoma 91%).
|
24223200 |
2013 |
leukemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Therefore, the existence of another genetic region linked to the MHC, causing segregation distortion, and containing recessive leukemia susceptibility genes may be postulated.
|
1610974 |
1992 |
Childhood Leukemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Therefore, the existence of another genetic region linked to the MHC, causing segregation distortion, and containing recessive leukemia susceptibility genes may be postulated.
|
1610974 |
1992 |
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
Additionally, circ-RanGAP1 silencing remarkably suppressed tumor growth and metastasis of GC in vivo.
|
31811909 |
2020 |
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Additionally, circ-RanGAP1 silencing remarkably suppressed tumor growth and metastasis of GC in vivo.
|
31811909 |
2020 |
Stomach Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Additionally, circ-RanGAP1 silencing remarkably suppressed tumor growth and metastasis of GC in vivo.
|
31811909 |
2020 |
Autism Spectrum Disorders
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We discuss the possibility that segregation distortion during spermatogenesis accounts for a subset of ASD mutations.
|
28733602 |
2017 |
Amyotrophic Lateral Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
RanGAP physically interacts with HRE RNA and is mislocalized in HRE-expressing flies, neurons from C9orf72 ALS patient-derived induced pluripotent stem cells (iPSC-derived neurons), and in C9orf72 ALS patient brain tissue.
|
26308891 |
2015 |
Glioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Inhibition of RNA transportation induces glioma cell apoptosis via downregulation of RanGAP1 expression.
|
25746355 |
2015 |
Ectrodactyly
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Data shown here provides further evidence for the contribution of DLX5 point mutations to the development of ectrodactyly and suggest the possibility of sex-related segregation distortion with an excess of affected males.
|
25196357 |
2014 |
Split-Hand/Foot Malformation
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Data shown here provides further evidence for the contribution of DLX5 point mutations to the development of ectrodactyly and suggest the possibility of sex-related segregation distortion with an excess of affected males.
|
25196357 |
2014 |
Split hand foot deformity 1
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Data shown here provides further evidence for the contribution of DLX5 point mutations to the development of ectrodactyly and suggest the possibility of sex-related segregation distortion with an excess of affected males.
|
25196357 |
2014 |
Burkitt Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
RanGAP1 was also highly expressed in other B-cell lymphomas (BCL, n = 180) with brisk mitotic activity (B-lymphoblastic lymphoma/leukemia: 93%, and Burkitt lymphoma: 95%) or cell-cycle dysregulation (mantle cell lymphoma: 83%, and Hodgkin's lymphoma 91%).
|
24223200 |
2013 |
Hodgkin Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
RanGAP1 was also highly expressed in other B-cell lymphomas (BCL, n = 180) with brisk mitotic activity (B-lymphoblastic lymphoma/leukemia: 93%, and Burkitt lymphoma: 95%) or cell-cycle dysregulation (mantle cell lymphoma: 83%, and Hodgkin's lymphoma 91%).
|
24223200 |
2013 |