RAP1A, RAP1A, member of RAS oncogene family, 5906

N. diseases: 215; N. variants: 7
Disease: Obesity ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity 		0.140 Biomarker disease BEFREE As hepatic steatosis and obesity have been related to increased liver cancer in mice and humans, we set out to address whether RAP1 deficiency resulted in increased liver cancer upon chemical liver carcinogenesis. 30307978 2018
CUI: C0028754
Disease: Obesity
Obesity 		0.140 Biomarker disease BEFREE (2013) now extend this link, demonstrating that deletion of the telomere binding protein RAP1 leads to obesity and insulin resistance. 23809762 2013
CUI: C0028754
Disease: Obesity
Obesity 		0.140 Biomarker disease BEFREE Gene expression analyses of liver and visceral white fat from Rap1-deficient mice before the onset of obesity show deregulation of metabolic programs, including fatty acid, glucose metabolism, and PPARα signaling. 23791526 2013
CUI: C0028754
Disease: Obesity
Obesity 		0.140 Biomarker disease BEFREE Nontelomeric role for Rap1 in regulating metabolism and protecting against obesity. 23791522 2013
CUI: C0028754
Disease: Obesity
Obesity 		0.140 Biomarker disease HPO