Celiac Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Common variation in IL2/IL21, RGS1, IL12A/SCHIP and SH2B3 was associated with susceptibility to CD in our Italian cohort.
|
18805825 |
2009 |
Celiac Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We independently confirmed association in two further collections (strongest association at rs6822844, 24 kb 5' of IL21; meta-analysis P = 1.3 x 10(-14), odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease.
|
17558408 |
2007 |
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Duodenal tissues from patients with untreated celiac disease had increased levels of mRNAs encoding IL15 receptor subunit alpha (IL15RA) and IL21 compared with tissues from patients with potential celiac disease and controls.
|
31622625 |
2020 |
Celiac Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Blockade of IL-21 activity by a neutralizing IL-21 Ab reduced IL-17A expression in cultures of active CD and peptic-tryptic digest of gliadin-treated CD biopsy specimens.
|
20061410 |
2010 |
Celiac Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Five SNPs strongly associated with celiac disease within the KIAA1109/TENR/IL2/IL21 linkage disequilibrium block on chromosome 4q27 and one coding SNP within the IL21 gene were analyzed in a large German IBD cohort.
|
19455118 |
2009 |
Celiac Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Based on this review, we performed genetic analysis of the MYO9B gene and the IL-2/IL-21 locus by genotyping SNPs that have been previously associated with coeliac disease or schizophrenia in 223 families, 108 unrelated individuals with schizophrenia and 120 controls.
|
21688385 |
2011 |
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results demonstrate that an IL-17A-independent increase in IL-21 production by CD4(+) T cells is characteristic of pediatric CD.
|
23571506 |
2013 |
Celiac Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recently, association of celiac disease with common single-nucleotide polymorphism (SNP) variants in an extensive linkage-disequilibrium block of 480 kb containing the KIAA1109, Tenr, IL2, and IL21 genes has been demonstrated in three independent populations (rs6822844P combined=1.3 x 10(-14)).
|
17999365 |
2007 |
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recent genome-wide association studies have identified 1q31 (RGS1), 2q11-12 (IL18RAP), 3p21 (CCR1/CCR3/CCR2), 3q25-26 (IL12A/SCHIP1), 3q28 (LPP), 4q27 (IL2/IL21), 6q25 (TAGAP) and 12q24 (SH2B3) as susceptibility regions for coeliac disease (CD).
|
19693089 |
2010 |
Celiac Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In children with coeliac disease, the genes coding for pro-inflammatory cytokines IFN-γ, IL-11, IL-18, and IL-21 were significantly overexpressed, suggesting the possible importance of these cytokines in the relationships between coeliac disease and dental disorders.
|
26440733 |
2016 |
Celiac Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression levels of the IL21 and Trx genes were not significantly modulated in the CD group compared to the control group, whereas the IL17A gene in CD patients was transcribed at significantly higher levels among the CD group.
|
30183349 |
2018 |
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
To examine whether interleukin 21 (IL21), a cytokine that regulates T cell activation, has a role in CD.
|
17965065 |
2008 |
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-21 was highly produced by CD4+ and CD4+/CD8+ IELs and LPLs in active CD.
|
22785229 |
2013 |
Celiac Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide analysis of extended pedigrees confirms IL2-IL21 linkage and shows additional regions of interest potentially influencing coeliac disease risk.
|
22077623 |
2011 |
Celiac Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Certain gene polymorphisms of IL2/IL21 (rs6822844 and rs6840978) and SH2B3 (rs3184504) may influence susceptibility to CD, although the effects remain unclear.
|
26535636 |
2015 |
Celiac Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our genome-wide association study of celiac disease previously identified risk variants in the IL2-IL21 region.
|
18311140 |
2008 |
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, our results support the KIAA1109/Tenr/IL2/IL21 region as a true CD susceptibility region.
|
18418394 |
2008 |
Celiac Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The four single nucleotide polymorphisms (SNPs) in the IL2/IL21 locus most associated with coeliac disease were genotyped in 1590 subjects with IBD and 929 controls from The Netherlands, and then replicated in a North American cohort (2387 cases and 1266 controls) and an Italian cohort (805 cases and 421 controls), yielding a total of 4782 cases (3194 UC, 1588 CD) and 2616 controls.
|
19201773 |
2009 |
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
This region harbors the interleukin 2 (IL2) and interleukin 21 (IL21) genes and was recently shown to be associated with four autoimmune diseases (Celiac disease, Type 1 diabetes, Grave's disease and Rheumatoid Arthritis).
|
18369459 |
2008 |
Lupus Erythematosus, Systemic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Additionally, silencing MALAT-1 significantly reduced the expression of IL-21 in primary monocytes of SLE patients.
|
29100395 |
2017 |
Lupus Erythematosus, Systemic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Given the inconsistent results from these studies, the present meta-analysis aimed to obtain a more precise estimate of the association between IL-21 rs907715 and rs2221903 polymorphisms and SLE.
|
26345892 |
2015 |
Lupus Erythematosus, Systemic
|
0.400 |
Biomarker
|
disease |
BEFREE |
The mutation disrupts a repressor of ICOS, an essential co-stimulatory receptor for follicular T cells, and results in excessive production of the cytokine interleukin-21. sanroque mice fail to repress diabetes-causing T cells, and develop high titres of autoantibodies and a pattern of pathology consistent with lupus.
|
15917799 |
2005 |
Lupus Erythematosus, Systemic
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-21 drives expansion and plasma cell differentiation of autoreactive CD11c<sup>hi</sup>T-bet<sup>+</sup> B cells in SLE.
|
29717110 |
2018 |
Lupus Erythematosus, Systemic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Suppression of OAZ expression inhibited downstream ID levels, and secretion of ANA and IL-21, implicating a role of OAZ pathway in the pathogenesis of SLE.
|
20359360 |
2010 |
Lupus Erythematosus, Systemic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Moreover, genotypes carrying the IL-21 rs2055979 A variant allele were associated with increased IL-21 levels compared to the homozygous wild-type genotype in patients with SLE.
|
24434811 |
2014 |