|
IMMUNODEFICIENCY, COMMON VARIABLE, 11
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Early-onset inflammatory bowel disease and common variable immunodeficiency-like disease caused by IL-21 deficiency.
|
24746753 |
2014 |
|
IMMUNODEFICIENCY, COMMON VARIABLE, 11
|
0.700 |
GermlineCausalMutation
|
disease |
ORPHANET |
Early-onset inflammatory bowel disease and common variable immunodeficiency-like disease caused by IL-21 deficiency.
|
24746753 |
2014 |
|
IMMUNODEFICIENCY, COMMON VARIABLE, 11
|
0.700 |
GeneticVariation
|
disease |
UNIPROT |
Early-onset inflammatory bowel disease and common variable immunodeficiency-like disease caused by IL-21 deficiency.
|
24746753 |
2014 |
|
IMMUNODEFICIENCY, COMMON VARIABLE, 11
|
0.700 |
GermlineCausalMutation
|
disease |
ORPHANET |
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor.
|
19890111 |
2009 |
|
IMMUNODEFICIENCY, COMMON VARIABLE, 11
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Duodenal tissues from patients with untreated celiac disease had increased levels of mRNAs encoding IL15 receptor subunit alpha (IL15RA) and IL21 compared with tissues from patients with potential celiac disease and controls.
|
31622625 |
2020 |
|
Lupus Erythematosus, Systemic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Additionally, IL-21 levels were significantly increased in samples from patients with Systemic Lupus Erythematosus (mean+/- SD: n = 14, 202.64 +/- 111.47 fg/mL, p = .0001 for Quanterix SiMoA and 275.4 +/- 174.66 fg/mL p = .0001 for MSD S-PLEX®) as well as in samples from patients with Sjögren's Syndrome (mean+/- SD: n = 11, 122.18 +/- 84.50 fg/mL, p = .0029 for Quanterix SiMoA and 183.64 +/- 153.00 fg/mL, p = .0082 for MSD S-PLEX®) when compared to healthy donors (mean+/- SD: n = 11, 38.1 +/- 27.8 fg/mL for Quanterix SiMoA and 58.1 +/- 30.7 fg/mL for MSD S-PLEX®).
|
30590020 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Altogether, our results indicate that β2-Glycoprotein I is able to elicit a local Interleukin-17/Interleukin-21 and Interferon-γ inflammation in lupus-antiphospholipid syndrome patients that might lead, if unabated, to plaque instability and subsequent arterial thrombosis, suggesting that the T helper 17/T helper 1 pathway may represent a novel target for the prevention and treatment of the disease.
|
30872365 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.400 |
Biomarker
|
disease |
BEFREE |
PD-1hiCXCR5- T peripheral helper cells promote B cell responses in lupus via MAF and IL-21.
|
31536480 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We aimed to determine whether single nucleotide polymorphisms (SNP) near the IL-21 gene have significant association with SLE susceptibility and the T helper-related inflammatory cytokine profile of SLE patients.
|
30774014 |
2019 |
|
Celiac Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression levels of the IL21 and Trx genes were not significantly modulated in the CD group compared to the control group, whereas the IL17A gene in CD patients was transcribed at significantly higher levels among the CD group.
|
30183349 |
2018 |
|
Lupus Erythematosus, Systemic
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-21 drives expansion and plasma cell differentiation of autoreactive CD11c<sup>hi</sup>T-bet<sup>+</sup> B cells in SLE.
|
29717110 |
2018 |
|
Lupus Erythematosus, Systemic
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-21-driven mTOR activation is a pharmacologically targetable checkpoint of the deficient autophagy that underlies Treg cell dysfunction in SLE.
|
29161463 |
2018 |
|
Lupus Erythematosus, Systemic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Enhanced ABC formation in SWEF-deficient mice was controlled by the cytokine IL-21 and IRF5, whose variants are strongly associated with lupus.
|
29483597 |
2018 |
|
Lupus Erythematosus, Systemic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Additionally, silencing MALAT-1 significantly reduced the expression of IL-21 in primary monocytes of SLE patients.
|
29100395 |
2017 |
|
Lupus Erythematosus, Systemic
|
0.400 |
Biomarker
|
disease |
BEFREE |
T follicular helper cells, interleukin-21 and systemic lupus erythematosus.
|
27498357 |
2017 |
|
Lupus Erythematosus, Systemic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Anti-IL-21 treatment also led to a reduction in GC B cells, CD138<sup>hi</sup> plasmablasts, IFN-γ-dependent IgG2c production, and autoantibodies, indicating that Tfh cell-derived IL-21 is critical for pathological B cell cues in lupus.
|
28219887 |
2017 |
|
Lupus Erythematosus, Systemic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we evaluated ROCK activity in a new SLE cohort, and an RA cohort, and assessed the ability of distinct inhibitors of the ROCK pathway to suppress production of IL-17 and IL-21 by SLE T cells or human Th17 cells.
|
28283529 |
2017 |
|
Celiac Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In children with coeliac disease, the genes coding for pro-inflammatory cytokines IFN-γ, IL-11, IL-18, and IL-21 were significantly overexpressed, suggesting the possible importance of these cytokines in the relationships between coeliac disease and dental disorders.
|
26440733 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
An elevated level of IL-21 was found in SLE CD4<sup>+</sup> T cells.
|
27818202 |
2016 |
|
Celiac Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Certain gene polymorphisms of IL2/IL21 (rs6822844 and rs6840978) and SH2B3 (rs3184504) may influence susceptibility to CD, although the effects remain unclear.
|
26535636 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Given the inconsistent results from these studies, the present meta-analysis aimed to obtain a more precise estimate of the association between IL-21 rs907715 and rs2221903 polymorphisms and SLE.
|
26345892 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Moreover, genotypes carrying the IL-21 rs2055979 A variant allele were associated with increased IL-21 levels compared to the homozygous wild-type genotype in patients with SLE.
|
24434811 |
2014 |
|
Lupus Erythematosus, Systemic
|
0.400 |
Biomarker
|
disease |
BEFREE |
T cells contribute to lupus pathogenesis by secreting pro-inflammatory cytokines such as IL-17, and by interacting with B cells and secreting helper factors such as IL-21 that promote production of IgG autoantibodies.
|
24508410 |
2014 |
|
Lupus Erythematosus, Systemic
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, genetic deficiency of IL-21 associates with inflammatory bowel diseases and blockade of IL-21 in the early phases exacerbates the disease progression in some models of rheumatoid arthritis and systemic lupus erythematosus, thus suggesting a dual role of IL-21 in the control of immune-mediated diseases.
|
25162763 |
2014 |